货号：AB19032

品牌：Merck Millipore

规格：

目录价：￥4383.00

市场价格：￥3725.55

会员价格：￥3506.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-ADAM 12 Antibody, C-terminus | AB19032 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: ADAM 12, cross reactivity with other ADAM family members untested. View All» Epitope: C-terminus View All» Immunogen: 13 amino acid synthetic peptide from the C-terminous of the protein (HQVPRPSHNAYIK) View All» Species Reactivity: Mouse View All» Application Notes: Western blot: 1:500-1:2000; purified milk proteins or BSA (2-3%) for blocking as milk can contain ADAMs and lower sensitivity. Do not dilute the primary antibody in milk; Simple TBS or PBS is recommended. Variable size on gel expected, as there are several processed forms of the protein. ~116-96kDa proforms, with 68kDa active forms predominately. IP: not tested FACS: Not suitable Optimal working dilutions must be determined by end user. View All» Applications Not Recommended: Flow Cytometry View All» Presentation: Neat rabbit serum. Contains no preservative. View All» Storage Conditions: Maintain frozen at -20°C in undiluted aliquots for up to 6 months. View All» UniProt Number: O43184 View All» Entrez Gene Number:

• NM_003474.3

• NM_021641.2
  View All» Gene Symbol:
  • ADAM12

  • Meltrin-alpha

  • MLTN

  • MCMP

  • MLTNA

  • Mltna

  • OTTHUMP00000046766

  • MCMPMltna

  • EC 3.4.24.-
    View All» Alternate Names: Meltrin alpha View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene has two alternatively spliced transcripts: a shorter secreted form and a longer membrane-bound form. The shorter form is found to stimulate myogenesis. View All» UniProt Summary: FUNCTION: SwissProt: O43184 # Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity).COFACTOR: Binds 1 zinc ion per subunit.SIZE: 909 amino acids; 99641 Da SUBUNIT: Interacts with alpha-actinin-2 and with syndecans (By similarity). Interacts with SH3PXD2A.SUBCELLULAR LOCATION: Isoform 12L: Cell membrane; Single-pass type I membrane protein. & Isoform 12S: Secreted.TISSUE SPECIFICITY: Isoform 12L is expressed in placenta and skeletal, cardiac, and smooth muscle. Isoform 12S seems to be expressed only in placenta or in embryo and fetus. Both forms were expressed in some tumor cells lines. Not detected in brain, lung, liver, kidney or pancreas.DOMAIN: SwissProt: O43184 The cysteine-rich domain supports cell adhesion through syndecans and triggers signaling events that lead to beta-1 integrin-dependent cell spreading. In carcinomas cells the binding of this domain to syndecans does not allow the integrin-mediated cell spreading. & The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.PTM: The precursor is cleaved by a furin endopeptidase (By similarity).SIMILARITY: Contains 1 disintegrin domain. & Contains 1 EGF-like domain. & Contains 1 peptidase M12B domain. View All» Brand Family: Chemicon View All» Product Name: Anti-ADAM 12 Antibody, C-terminus | AB19032 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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