货号：AB1923

品牌：Merck Millipore

规格：100UL

目录价：￥4755.00

市场价格：￥4041.75

会员价格：￥3804.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Integrin αV Antibody, cytoplasmic domain | AB1923 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Integrin alphaV View All» Epitope: cytoplasmic domain View All» Immunogen: Synthetic peptide corresponding to amino acids 1035-1048 of human integrin alphaV. This peptide sequence is absolutely conserved in the mouse integrin alphaV sequence. View All» Species Reactivity: Human View All» Application Notes: ELISA: 1:500 (direct) Western Blot: 1:500. Antibody detects a non-reducible 155 kDa band corresponding to integrin alphaV. Optimal dilutions must be determined by the end user. View All» Presentation: Whole rabbit serum. Liquid containing no preservative View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P06756 View All» Entrez Gene Number: NM_002210.2 View All» Gene Symbol:

• ITGAV

• DKFZp686A08142

• MSK8

• CD51

• VNRA
  View All» Alternate Names: Vitronectin Receptor alpha Subunit; CD51 Antigen View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Western Blotting
    View All» Entrez Gene Summary: ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. View All» UniProt Summary: FUNCTION: SwissProt: P06756 # The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and von Willebrand factor. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.SIZE: 1048 amino acids; 116038 Da SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8 subunit. Interacts with HIV-1 Tat.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.SIMILARITY: SwissProt: P06756 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats. View All» Brand Family: Chemicon View All» Product Name: Anti-Integrin αV Antibody, cytoplasmic domain | AB1923 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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