货号：AB1924

品牌：Merck Millipore

规格：100UL

目录价：￥5207.00

市场价格：￥4425.95

会员价格：￥4165.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Integrin α4 Antibody, cytoplasmic on C-terminus | AB1924 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Integrin alpha 4. Specificity determined by immunoprecipitation from a detergent extract of 35S methionine-labeled lymphoid cells. No cross-reactivity to alpha 1, alpha 2, alpha 3, alpha 5, alpha 6 or alpha V. The antibody recognizes an epitope on the cytoplasmic domain of the protein, and it is thus intracellular. View All» Epitope: cytoplasmic domain, C-terminus View All» Immunogen: Synthetic peptide derived from the COOH terminal sequence (cytoplasmic domain) of the human alpha 4 integrin subunit. View All» Species Reactivity:

• Chicken

• Human

• Hamster

• Mouse

• Pig

• Rat
  View All» Application Notes: ELISA/RIA: 1:1000. Western blot: 1:1000, non-reduced conditions; blocking should be with 1-3% BSA. Recognizes a 140 kDa human alpha 4 band under non-reducing conditions. Immunohistochemistry: 1:500 Immunoprecipitation: 5 μL of antibody is sufficient to precipitate alpha4 from 5x106 cells. Optimal working dilutions must be determined by end user. View All» Presentation: Liquid rabbit antiserum with 0.05% sodium azide. View All» Storage Conditions: Maintain at -20ºC in undiluted aliquots for up to 12 months upon date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P13612 View All» Entrez Gene Number: NM_000885.4 View All» Gene Symbol:
  • ITGA4

  • MGC90518

  • VLA-4

  • IA4

  • CD49D

  • CD49d
    View All» Alternate Names: CD49d View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Immunoprecipitation

    • Radioimmunoassay

    • Western Blotting

    • Immunohistochemistry
      View All» Entrez Gene Summary: The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain. View All» UniProt Summary: FUNCTION: SwissProt: P13612 # Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha- 4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha- 4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.SIZE: 1038 amino acids; 115333 Da SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit can sometimes be cleaved into two non-covalently associated fragments. Alpha-4 associates with either beta-1 or beta-7. Alpha-4 interacts with PXN, LPXN, and TGFB1I1/HIC5. Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.DOMAIN: SwissProt: P13612 The SG1 motif is involved in binding to chondroitin sulfate glycosaminoglycan and cell adhesion.PTM: Phosphorylation on Ser-1027 inhibits PXN binding.SIMILARITY: Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats. View All» Brand Family: Chemicon View All» Product Name: Anti-Integrin α4 Antibody, cytoplasmic on C-terminus | AB1924 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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