货号：AB1926

品牌：Merck Millipore

规格：100UL

目录价：￥5207.00

市场价格：￥4425.95

会员价格：￥4165.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Integrin β5 Antibody, C-terminus/cytosolic | AB1926 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes Integrin beta5. Specificity determined by immunoprecipitation from detergent extract of 35S methionine labeled cells. No cross-reactivity to beta1 or beta3. View All» Molecular Weight: 88 kDa View All» Epitope: C-terminus/cytosolic View All» Immunogen: Synthetic peptide derived from the COOH terminal sequence (cytoplasmic domain) of the human integrin beta 5 subunit (KTFNKFNKSYNGTVD). Note : a lysine (K) residue was added to the N-terminal of the peptide to facilitate coupling to the carrier protein. View All» Background Information: The integrin family of cell adhesion receptors consists of at least 16 membrane-associated heterodimers, composed of an alpha and beta subunit that associate in a non-covalent manner. The structure and functional diversity of the integrin family are based upon the pairing abilities of the individual alpha and beta subunits. Key to these molecular interactions between the integrin receptors and their respective ligands is the recognition of the Arg-Gly-Asp (RGD) sequence, known to be present in the extracellular matrix components fibronectin, vitronectin, collagen, fibrinogen, and von Willebrand factor (Cheresh, 1991). The involvement of integrins in vascular proliferation, adhesion, and wound repair has been well documented. The beta5 subunit associates with alphaV forming a receptor for vitronectin. This complex is expressed in a wide range of cell types including fibroblast and keratinocytes. It is also expressed at high levels in several tumors including lung, pancreatic and mammary carcinomas. It is not expressed in lymphblastoid cells. View All» Species Reactivity:

• Human

• Hamster

• Mouse

• Rat
  View All» Application Notes: ELISA/RIA Immunoprecipitation: 5μL of antibody is sufficient to precipitate alphaVbeta5 from 2.5x10E6 cells. Western blot: non-reduced conditions; do not use milk in the dilution buffer. Immunofluorescence: 1:100. Immunohistochemistry (Acetone Fixed) 1:40-1:80 Immunohistochemistry (Paraffin Embedded) 1:200 (ABC) Optimal working dilutions must be determined by end user. View All» Control: Skin (Basement Membrane) View All» Purification Method: Unpurified View All» Presentation: UnPurified whole rabbit Serum containing 0.05% sodium azide as a preservative. View All» Storage Conditions: Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. View All» UniProt Number: P18084 View All» Entrez Gene Number: NM_002213.3 View All» Gene Symbol:
  • ITGB5

  • FLJ26658
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Immunofluorescence

    • Immunohistochemistry (Paraffin)

    • Immunoprecipitation

    • Radioimmunoassay

    • Western Blotting
      View All» UniProt Summary: FUNCTION: SwissProt: P18084 # Integrin alpha-V/beta-5 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.SIZE: 799 amino acids; 88054 Da SUBUNIT: Heterodimer of an alpha and a beta subunit. Beta-5 associates with alpha-V.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.SIMILARITY: SwissProt: P18084 ## Belongs to the integrin beta chain family. & Contains 1 PSI domain. & Contains 1 VWFA domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Integrin β5 Antibody, C-terminus/cytosolic | AB1926 View All» Concentration: Variable View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μL View All» Format: Serum View All» Host: Rabbit View All»
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