货号:AB1955
品牌:Merck Millipore
规格:
目录价:¥4645.00
市场价格:¥3948.25
会员价格:¥3716.00
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Description:
Anti-VE-Cadherin Antibody, phospho-specific [Tyr658] | AB1955
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Promotional Text:
Special Shipping Offer on Antibodies100% Performance Guaranteed
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Trade Name:
Chemicon (Millipore)
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Specificity:
The antibody detects a 120 kDa protein of VE-cadherin.
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Immunogen:
Phosphorylated VE-cadherin (Tyr658) synthetic peptide corresponding to human amino acid residues around tyrosine 658. The sequence is conserved in mouse, rat, porcine, bovine, canine, chicken and chimpanzee.
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Modifications:
Phosphorylation
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Background Information:
VE-cadherin is an endothelial specific adhesion molecule that is essential for the maintenance of endothelial barrier function and angiogenesis. It is linked to the actin cytoskeleton through a number of adaptor proteins including alpha, beta, and gamma catenin. Cytoskeletal dynamics and phosphorylation regulate VE-cadherin mediated cellcell adhesion. The interaction between cytosolic c-terminal Src kinase, SH2 domain and phosphorylated tyrosine 658 site of VE-Cadherin regulates density dependent cell proliferation. Phosphorylation of tyrosine 658 has been shown to lead to uncoupling of p120-catenin from the cytoplasmic tail of VE-cadherin. This phosphorylation event is sufficient to maintain cells in a mesenchymal state during the cell invasion phase of angiogenesis.
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Species Reactivity:
Human
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Species Reactivity Note:
This sequence is 100% homologous in mouse, rat, chicken, chimpanzee, cow, dog and pig VE-cadherin.
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Presentation:
Antibody is purified from rabbit serum. It is cross-adsorbed to nonphospho-peptide corresponding to the site of phosphorylation then affinity purified using phosphorylated VEcadherin (Tyr658) peptide. Antibody is supplied in 100 µl phosphate-buffered saline (no Ca2+, no Mg2+), pH 7.3, 50% glycerol, containing 1 mg/ml BSA, and 0.05% sodium azide.
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Storage Conditions:
Maintain at -20°C for up to one year or 2°-8°C for short term storage from date of receipt. Avoid repeated freeze/thaw cycles.
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UniProt Number:
P33151
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Entrez Gene Number:
NM_001795.2
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Gene Symbol:
-
CDH5
-
VE-cadherin
-
CD144
-
7B4
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
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Entrez Gene Summary:
This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but its full length sequence has not been determined.
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UniProt Summary:
FUNCTION: SwissProt: P33151 # Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton.SIZE: 784 amino acids; 87516 Da SUBCELLULAR LOCATION: Cell junction. Cell membrane; Single-pass type I membrane protein (Probable). Note=Found at cell-cell boundaries and probably at cell-matrix boundaries.TISSUE SPECIFICITY: Endothelial tissues and brain.SIMILARITY: SwissProt: P33151 ## Contains 5 cadherin domains.
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Brand Family:
Chemicon
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Product Name:
Anti-VE-Cadherin Antibody, phospho-specific [Tyr658] | AB1955
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Antibody Type:
Polyclonal Antibody
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Qty/Pk:
100 µL
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Format:
Affinity Purified
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Host:
Rabbit
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