货号：AB1956

品牌：Merck Millipore

规格：

目录价：￥4621.00

市场价格：￥3927.85

会员价格：￥3696.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-VE-Cadherin Antibody, phospho-specific [Tyr731] | AB1956 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: The antibody detects a 120 kDa protein corresponding to VE-cadherin. View All» Molecular Weight: 120 kDa View All» Epitope: Tyr731 View All» Immunogen: Synthetic peptide corresponding to amino acid residues surrounding and including tyrosine 731 (phosphorylated) of human VE-Cadherin. The immunogen sequence is 100% identical in chimpanzee, mouse, rat, chicken, zebrafish, cow, dog and 91% identical in pig VE-cadherin. View All» Modifications: Phosphorylation View All» Background Information: VE-cadherin is an endothelial specific adhesion molecule that is essential for the maintenance of endothelial barrier function and angiogenesis. It is linked to the actin cytoskeleton through a number of adaptor proteins including alpha, beta, and gamma catenin. Cytoskeletal dynamics and phosphorylation regulate VE-cadherin mediated cell-cell adhesion. Phosphorylation of tyrosine 731 leads to the separation of beta-catenin from the cytoplasmic tail of VE-cadherin. This phosphorylation event is sufficient to maintain cells in a mesenchymal state during the cell invasion phase of angiogenesis. View All» Species Reactivity: Human View All» Application Notes: Western Blot: 1:1000. Optimal working dilutions must be determined by the end user. View All» Purification Method: Immunoaffinity purified View All» Presentation: Antibody is cross-adsorbed to nonphospho-peptide corresponding to the site of phosphorylation then affinity purified using phosphorylated VE-cadherin (Tyr731) peptide. Antibody is supplied in 100 μL phosphate-buffered saline (no Ca²⁺, no Mg²⁺), pH 7.3, 50% glycerol, 1 mg/mL BSA, and 0.05% sodium azide. View All» Storage Conditions: Maintain at -20°C for up to one year from date of receipt. Avoid repeated freeze/thaw cycles. May be stored for short periods at 2-8°C. View All» UniProt Number: P33151 View All» Entrez Gene Number: NM_001795.2 View All» Gene Symbol:

• CDH5

• VE-cadherin

• CD144

• 7B4
  View All» Alternate Names: Cadherin-5; Vascular endothelial-cadherin; CD144 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but its full length sequence has not been determined. View All» UniProt Summary: FUNCTION: SwissProt: P33151 # Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton.SIZE: 784 amino acids; 87516 Da SUBCELLULAR LOCATION: Cell junction. Cell membrane; Single-pass type I membrane protein (Probable). Note=Found at cell-cell boundaries and probably at cell-matrix boundaries.TISSUE SPECIFICITY: Endothelial tissues and brain.SIMILARITY: SwissProt: P33151 ## Contains 5 cadherin domains. View All» Brand Family: Chemicon View All» Product Name: Anti-VE-Cadherin Antibody, phospho-specific [Tyr731] | AB1956 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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