金山科研平台，产品价格货期咨询微信：jinshanbio Assay Type:ELISA Development Kit for intracellular proteins Assay Length:4 hours 40 mins (after plate preparation) Sample Type & Volume Required:Cell lysates (100 µL) Sufficient Materials:Kits available for two, five, or fifteen 96-well plates* Range:62.5 - 4,000 pg/mL Specificity:Please see the product datasheet Molecule Information: SMAC/Diablo Long Name: Second Mitochondria-derived Activator of Caspase Aliases: Diablo Entrez Gene IDs: 56616 (Human) Background: SMAC/Diablo SMAC (second mitochondria-derived activator of caspase)/Diablo, the mammalian functional homologue of Drosophila Hid, Grim, and Reaper, regulates apoptosis by neutralizing inhibitor of apoptosis (IAP) proteins. IAP family members contain one to three baculovirus IAP repeat (BIR) domains, each exhibiting distinct functions and caspase specificity. The BIR2 domain inhibits caspase-3 and –7, whereas the BIR3 domain inhibits caspase-9 activity. SMAC/Diablo interacts with BIR2 and BIR3 domains of IAPs, thereby neutralizing IAP inhibition and promoting caspase catalytic activity and apoptosis.