货号：AB1967

品牌：Merck Millipore

规格：100UL

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Integrin αIIb Antibody, cytoplasmic domain | AB1967 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Human integrin alpha Iib View All» Epitope: cytoplasmic domain View All» Immunogen: Synthetic peptide corresponding to the cytoplasmic domain of human integrin alphaIIb conjugated to KLH. (a.a. 1020-1039, KVGFFKRNRPPLEEDDEEGE) View All» Species Reactivity: Human View All» Application Notes: Immunoprecipitation ELISA: Direct 1:500 with 5% milk in PBS or TBS at pH 7.4 Optimal working dilutions must be determined by the end user. View All» Presentation: Whole rabbit serum. Liquid containing no preservative. View All» Storage Conditions: Maintain at -20ºC in undiluted aliquots for up to twelve months from date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P08514 View All» Entrez Gene Number: NM_000419.3 View All» Gene Symbol:

• ITGA2B

• CD41B

• GPIIb

• HPA3

• GP2B

• ITGAB

• CD41

• GTA
  View All» Alternate Names: Glycoprotein IIb; CD41 Antigen View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Immunoprecipitation
    View All» Entrez Gene Summary: ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. View All» UniProt Summary: FUNCTION: SwissProt: P08514 # Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.SIZE: 1039 amino acids; 113391 Da SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-IIb associates with beta-3.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Isoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in reticulocytes or in Jurkat and U937 white blood cell line. Isoform 3 is expressed by leukemia, prostate adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells.DISEASE: SwissProt: P08514 # Defects in ITGA2B are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]; also known as thrombasthenia of Glanzmann and Naegeli. This autosomal recessive disorder is the most common inherited disease of platelets. GT is characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb/beta-3 complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the glycoprotein IIb/beta-3 complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT 'variants' have normal or near normal (60-100%) expression of dysfunctional receptors.SIMILARITY: SwissProt: P08514 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats. View All» Brand Family: Chemicon View All» Product Name: Anti-Integrin αIIb Antibody, cytoplasmic domain | AB1967 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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