货号：AB2043

品牌：Merck Millipore

规格：100Ug

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Elastin Antibody | AB2043 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Antibody shows less than 0.1% reactivity with human Collagen I, II, III, IV, V and human Fibronectin as well as Rat Elastin by radioimmunoassay. View All» Immunogen: Elastin extracted and purified from human skin. View All» Species Reactivity: Human View All» Non-Reactive Species: Rat View All» Application Notes: Immunohistochemistry: 1:80 dilution for immunofluorescent staining of frozen human skin and liver tissues. Radioimmunoassay ELISA Optimal working dilutions must be determined by end user. View All» Control: Control tissue: human skin or liver View All» Presentation: IgG fraction. Liquid in 0.01M Phosphate, 0.09M Sodium Chloride, pH 7.2, containing no preservatives. View All» Storage Conditions: Maintain frozen at -20°C for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P15502 View All» Entrez Gene Number:

• NM_000501.2

• NM_001081752.1

• NM_001081753.1

• NM_001081754.1

• NM_001081755.1
  View All» Gene Symbol:
  • ELN

  • tropoelastin

  • FLJ38671

  • SVAS

  • WS

  • Tropoelastin

  • elastin

  • FLJ43523

  • WBS
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Radioimmunoassay

    • Immunohistochemistry
      View All» Entrez Gene Summary: This gene encodes a protein that is one of the two components of elastic fibers. The encoded protein is rich in hydrophobic amino acids such as glycine and proline, which form mobile hydrophobic regions bounded by crosslinks between lysine residues. Deletions and mutations in this gene are associated with supravalvular aortic stenosis (SVAS) and autosomal dominant cutis laxa. Multiple transcript variants encoding different isoforms have been found for this gene. View All» UniProt Summary: FUNCTION: SwissProt: P15502 # Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity).SIZE: 786 amino acids; 68499 Da SUBUNIT: The polymeric elastin chains are cross-linked together into an extensible 3D network. Forms a ternary complex with BGN and MFAP2. Interacts with MFAP2 via divalent cations (calcium > magnesium > manganese) in a dose-dependent and saturating manner.SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix. Note=Extracellular matrix of elastic fibers.TISSUE SPECIFICITY: Expressed within the outer myometrial smooth muscle and throughout the arteriolar tree of uterus (at protein level). Also expressed in the large arteries, lung and skin.PTM: Elastin is formed through the cross-linking of its soluble precursor tropoelastin. Cross-linking is initiated through the action of lysyl oxidase on exposed lysines to form allysine. Subsequent spontaneous condensation reactions with other allysine or unmodified lysine residues result in various bi-, tri-, and tetrafunctional cross-links. The most abundant cross-links in mature elastin fibers are lysinonorleucine, allysine aldol, desmosine, and isodesmosine. & Hydroxylation on proline residues within the sequence motif, GXPG, is most likely 4-hydroxy as this fits the requirement for 4- hydroxylation in vertebrates (By similarity).DISEASE: SwissProt: P15502 # Defects in ELN are a cause of autosomal dominant cutis laxa [MIM:123700]. Cutis laxa is a rare connective tissue disorder characterized by loose, hyperextensible skin with decreased resilience and elasticity leading to a premature aged appearance. The skin changes are often accompanied by extracutaneous manifestations, including pulmonary emphysema, bladder diverticula, pulmonary artery stenosis and pyloric stenosis. & Haploinsufficiency of ELN may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS) [MIM:194050]. WBS is a rare developmental disorder and a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23. & Defects in ELN are the cause of supravalvular aortic stenosis (SVAS) [MIM:185500]. SVAS is a congenital narrowing of the ascending aorta which can occur sporadically, as an autosomal dominant condition, or as one component of Williams-Beuren syndrome.SIMILARITY: SwissProt: P15502 ## Belongs to the elastin family. View All» Brand Family: Chemicon View All» Product Name: Anti-Elastin Antibody | AB2043 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
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