货号：AB2204

品牌：Merck Millipore

规格：50UL

目录价：￥4967.00

市场价格：￥4221.95

会员价格：￥3973.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-BMAL1 Antibody | AB2204 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Cat. # AB2204 will recognize the C-terminus of BMAL1. View All» Molecular Weight: ~69 kDa. View All» Epitope: C-Terminus View All» Immunogen: Recombinant Protein View All» Background Information: Brain and muscle Arnt-like protein-1 (BMAL1; also known as MOP3 or Arnt3) is a transcription factor known to regulate circadian rhythm. BMAL1 is the only component of the mammalian circadian clock whose sole deletion in a mouse model generates arrhythmicity. In addition to defects in the clock, these BMAL1 null-mice also have reproductive problems are small in stature, age quickly and have progressive arthropathy that results in having less overall locomotor activity than wild type mice. Recent phenotyping data suggests that BMAL1 and its partner Clock also play a role in regulation of glucose homeostasis and metabolism. Finally, BMAL1, NPAS2, and PER2 have been associated with seasonal affective disorder in humans. BMAL1 transcription is circadian and reciprocally regulated by NR1D1 (Rev-erb-alpha) and RORA, which establishes a second interlocking loop in the mammalian circadian clock. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Mouse, Human and Rat. Reactivity with other species has not been tested. View All» Control: C2C12 Tissue lysate View All» Quality Assurance: Routinely tested on C2C12 tissue lysateLot Specific Tested Application 1: Western Blot View All» Presentation: Serum with 0.05% NaN3 View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 1 year after date of receipt. View All» UniProt Number: O00327 View All» Entrez Gene Number: NP_031515 View All» Gene Symbol:
  • BMAL1

  • BMAL1c

  • JAP3

  • MGC47515

  • MOP3

  • PASD3

  • TIC
    View All» Alternate Names:
    • ARNT-like protein 1, brain and muscle

    • Basic-helix-loop-helix-PAS protein MOP3

    • Brain and muscle ARNT-like 1

    • Member of PAS protein 3

    • aryl hydrocarbon receptor nuclear translocator-like

    • bHLH-PAS protein JAP3

    • basic-helix-loop-helix-PAS orphan MOP3 2 member of PAS superfamily 3
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: ARNTL-CLOCK heterodimers activate E-box element (3'-CACGTG-5') transcription of a number of proteins of the circadian clock. This transcription is inhibited in a feedback loop by PER, and also by CRY proteins (By similarity). SUBUNIT: Component of the circadian clock oscillator which includes the CRY proteins, CLOCK or NPAS2, ARNTL or ARNTL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Efficient DNA binding requires dimerization with another bHLH protein. Heterodimerization with CLOCK is required for E-box-dependent transactivation, for CLOCK nuclear translocation and degradation, and, for phosphorylation of both CLOCK and ARNTL. Interaction with PER and CRY proteins requires translocation to the nucleus. Interaction of the CLOCK-ARNTL heterodimer with PER or CRY inhibits transcription activation. Interacts with HSP90; with AHR in vitro, but not in vivo. SUBCELLULAR LOCATION: Nucleus (By similarity). ALTERNATIVE PRODUCTS: 8 named isoforms [FASTA] produced by alternative splicing. Additional isoforms seem to exist. View All» Product Name: Anti-BMAL1 Antibody | AB2204 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µL View All» Format: Serum View All» Host: Guinea Pig View All»
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