货号：AB2208

品牌：Merck Millipore

规格：

目录价：￥4095.00

市场价格：￥3480.75

会员价格：￥3276.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho STEP61/46 Antibody, (Ser221/Ser49) | AB2208 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes STEP61/46 when phosphorylated at Ser221/Ser49. View All» Molecular Weight: ~ 62 kDa observed UniProtKB/Swiss-Prot P54830 (PTN5_MOUSE) entry describes 4 isoforms produced by alternative splicing: Isoform STEP61 at 60.815 kDa, Isoform STEP46 at 42.341 kDa, Isoform STEP 38 at 38.238 kDa, Isoform STEP20 at 19.763 kDa. The immunizing sequence also has 100% homology to UniProtKB/Swiss-Prot Q62132 (PTPRR_MOUSE) ~74kDa (S338). Uncharacterized bands appear at ~21, 29, and 32 kDa. View All» Epitope: Phosphorylated Ser221/Ser49 View All» Immunogen: KLH-conjugated linear peptide corresponding to mouse STEP61/46 phosphorylated at Ser221/Ser49. View All» Background Information: Striatum-enriched protein-tyrosine phosphatase (STEP) isoforms 61 and 46 are two of the many splice variants for STEP, a protein belonging to the protein-tyrosine phosphatase family and containing a single tyrosine-protein phosphatase domain. STEP61 is membrane-associated, where as STEP46 is cytosolic. STEP61 also differs in that it contains a sequence of 172 amino acids with structural motifs not found in STEP46. Both isoforms are phosphorylated on serine residues, although STEP61 is mainly phosphorylated at Ser160 and Ser221, while STEP46 is phosphorylated at Ser49. STEP is thought to have a critical role in regulating dopamine efficacy on striatial medium spiny neurons, neurotransmission through the NMDAR pathway, and AMPA receptor endocytosis. View All» Species Reactivity:

• Mouse

• Human

• Rhesus Macaque

• Bovine

• Rat
  View All» Species Reactivity Note: Demonstrated to react with human and mouse. Predicted to react with rhesus monkey, bovine, and rat based on 100% sequence homology. View All» Application Notes: Immunohistochemistry Analysis: 1:600 dilution of this antibody from a previous lot detected phosphorylated STEP61/46 in caudata putamen region of adult human brain tissue. View All» Control: Mouse brain tissue lysate View All» Quality Assurance: Evaluated by Western Blot in mouse brain tissue lysate.Western Blot Analysis: 1 µg/mL of this antibody detected STEP61/46 on 10 µg of mouse brain tissue lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P54830 View All» Entrez Gene Number: NP_001157037 View All» Gene Symbol:
  • STEP

  • PTPSTEP

  • PTPN5

  • FLJ14427
    View All» Alternate Names:
    • protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)

    • protein-tyrosine phosphatase striatum-enriched

    • tyrosine-protein phosphatase non-receptor type 5

    • Striatum-enriched protein-tyrosine phosphatase

    • Neural-specific protein-tyrosine phosphatase
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry
        View All» UniProt Summary: CATALYTIC ACTIVITY: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.TISSUE SPECIFICTY: STEP20 is expressed only in the CNS.SEQUENCE SIMILARITIES: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.Contains 1 tyrosine-protein phosphatase domain. View All» Product Name: Anti-phospho STEP61/46, (Ser221/Ser49) View All» Concentration: 0.25 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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