货号：AB2209

品牌：Merck Millipore

规格：100UL

目录价：￥5513.00

市场价格：￥4686.05

会员价格：￥4410.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-ABBA Antibody | AB2209 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Cat. # AB2209 recognizes ABBA View All» Molecular Weight: ~82 kDa View All» Immunogen: Recombinant protein. View All» Background Information: Radial glia play key roles in neuronal migration, axon guidance, and neurogenesis during development of the central nervous system. However, the molecular mechanisms regulating growth and morphology of these extended cells are unknown. ABBA, a novel member of the IRSp53/MIM protein family, is enriched in different types of radial glia. ABBA binds ATP-actin monomers with high affinity and deforms PIP2-rich membranes in vitro through its WH2 and IMdomains, respectively. In radial glia-like C6-R cells, ABBA localizes to the interface between the actin cytoskeleton and plasma membrane, and its depletion by RNAi leads to defects in lamellipodial dynamics and process extension. Together, ABBA acts as a novel regulator of actin and plasma membrane dynamics in radial glial cells, and provides evidence that the membrane binding/deformation activity is critical for the cellular functions of IRSp53/MIM/ABBA family proteins View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Human, Mouse and Rat. May react with Pan troglodytes and Macaca mulatta based on sequence homology. Reactivity with other species was not tested. View All» Application Notes: Non-Lot Specific Tested Application 1:Immunocytochemistry: 1:50 dilution in mouse primary glial cell line and C6, C6-R rat cell line.Non-Lot Specific Tested Application 2: Immunohistochemistry: 1:1,000 in embryonic and adult brain tissue.(See Reference for more information) View All» Control: Mouse brain lysate View All» Quality Assurance: Routinely tested on mouse brain lysateLot Specific Tested Application 1: Western Blot View All» Presentation: Serum with with 0.05% NaN3 View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 1 year after date of receipt. View All» UniProt Number: Q6P9S0 View All» Entrez Gene Number: NP_941027 View All» Gene Symbol:
  • MGC79213

  • ABBA
    View All» Alternate Names: actin-bundling protein with BAIAP2 homology View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunocytochemistry

    • Immunohistochemistry
      View All» Product Name: Anti-ABBA Antibody | AB2209 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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