货号：AB2231

品牌：Merck Millipore

规格：100Ug

目录价：￥6281.00

市场价格：￥5338.85

会员价格：￥5024.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Dopamine Transporter; 100 µg Antibody | AB2231 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Cat. AB2231 recognizes the N-terminus of the reduced and non reduced forms of DAT. View All» Molecular Weight: ~ 50 – 80 kDaReduced form at approx 50 kDa and Non-reduced form at approx. 80 kDa View All» Epitope: N-terminus View All» Immunogen: Synthetic Linear Peptide View All» Background Information: Plasmalemmal neurotransmitter transporters sequester synaptic and peri synaptic transmitter into presynaptic elements. The Dopamine Transporter (DAT), a 12 transmembrane domain transporter with the N and C terminal regions located within the cytoplasm is responsible for the reaccumulation of dopamine after it has been released. Levels of DAT protein expression are altered by chronic drug administration. The activity of the DAT reuptake carrier is sodium dependent, and it is suspected to play a role in such neurologic and psychiatric disorders as Parkinson's disease, Tourette's disease, schizophrenia, and addiction. DAT is also the target of several “DAT-blockers” including amphetamines and cocaine. These chemicals inhibit the action of DAT and, to a lesser extent, the other monoamine transporters, but their effects are mediated by separate mechanisms. View All» Species Reactivity:

• Mouse

• Rat
  View All» Control: Rat Brain Lysate. View All» Quality Assurance: Routinelyevaluated by western blot on rat brain lysate. View All» Purification Method: Immunoaffinity purified View All» Presentation: Purified Antibody in PBS with 0.1% NaN3 View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt.Handling Recommendations: Prior to removing the cap, gently centrifuge the vial and gently mix the solution. View All» UniProt Number: Q01959 View All» Entrez Gene Number: NM_001044.3 View All» Gene Symbol:
  • DAT

  • DAT 1
    View All» Alternate Names:
    • DA transporter

    • dopamine transporter

    • solute carrier family 6 (neurotransmitter transporter, dopamine),member 3

    • variable number tandem repeat (VNTR)
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The dopamine transporter (DAT1) mediates the active reuptake of dopamine from the synapse and is a principal regulator of dopaminergic neurotransmission. The DAT1 gene has been implicated in human disorders such as parkinsonism, Tourette syndrome, and substance abuse (Vandenbergh et al., 1992 [PubMed 1359373]).[supplied by OMIM] View All» UniProt Summary: FUNCTION: Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals. SUBUNIT: Homooligomer; disulfide-linked. Interacts with PRKCABP and TGFB1I1. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. MISCELLANEOUS: This protein is the target of psychomotor stimulants such as amphetamines or cocaine. SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) family. View All» Product Name: Anti-Dopamine Transporter; 100 µg Antibody | AB2231 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：https://www.16ao.com/thread-152954.htm
      © Merck Millipore代理AB2231 Anti-Dopamine Transporter; 100 µg Antibody;store at +2℃ to +8℃，产品报价联系微信jinshanbio