货号：AB2232

品牌：Merck Millipore

规格：100Ug

目录价：￥4967.00

市场价格：￥4221.95

会员价格：￥3973.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Atrial Natriuretic Polypetide Antibody, alpha | AB2232 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Cat. # AB2232 recognizes ANP, alpha View All» Molecular Weight: ~17 kDa View All» Immunogen: Synthetic Linear Peptide View All» Background Information: Atrial natriuretic polypeptide, alpha (ANP), atrial natriuretic factor (ANF), or atriopeptin, is a protein (polypeptide) hormone secreted by heart muscle cells. It is involved in the homeostatic control of body water, sodium, potassium and fat (adiposity). It is released by muscle cells in the upper chambers (atria) of the heart (atrial myocytes), in response to high blood pressure. ANP acts to reduce the water, sodium and adipose loads on the circulatory system, thereby reducing blood pressure. ANP binds to a specific set of receptors - ANP receptors. Receptor-agonist binding causes a reduction in blood volume and therefore a reduction in cardiac output and systemic blood pressure. Lipolysis is increased and renal sodium reabsorption is decreased. The overall effect of ANP on the body is to counter increases in blood pressure and volume caused by the renin-angiotensin system (1). View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Rat, Human and Mouse. May react with dog, cat and cow based on sequence homology. View All» Application Notes: Non-Lot Specific Tested Application 1:Immunohistochemistry: 1:50-1:500 on paraffin embedded tissue.Optimum dilutions need to be determined by the end user. View All» Control: Rat Heart View All» Quality Assurance: Routinely evaluated by western blot View All» Purification Method: Purified View All» Presentation: Purified in 0.1M Tris-Glycine (pH7.4) 15mM NaCl with 0.05% NaN3 View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt.Handling Recommendations: Prior to removing the cap, gently centrifuge the vial and gently mix the solution. View All» UniProt Number: P01160 View All» Entrez Gene Number: NP_006163.1 View All» Gene Symbol:
  • ANF

  • ANP

  • CDD-ANF

  • OTTHUMP00000002504

  • OTTHUMP00000044485

  • PND

  • Prepronatriodilatin

  • pronatriodilatin
    View All» Alternate Names:
    • Atrial natriuretic peptide

    • natriuretic peptide precursor A

    • natriuretic peptide precursor A variant 2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: A potent vasoactive substance which is thought to play a key role in cardiovascular homeostasis. Has a cGMP-stimulating activity. SUBUNIT: Interacts with NPR3. LOCATION: Secreted. POLYMORPHISM: There are two different prepronatriodilatin alleles. One codes for 2 Arg residues at the C-terminus that are cleaved to form the mature peptide, while the other ends in a termination codon immediately after the last codon of the mature peptide. SIMILARITY: Belongs to the natriuretic peptide family. View All» Product Name: Anti-Atrial Natriuretic Polypetide Antibody, alpha | AB2232 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
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