货号：AB2241

品牌：Merck Millipore

规格：

目录价：￥4095.00

市场价格：￥3480.75

会员价格：￥3276.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-SUR1 Antibody | AB2241 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes SUR1. View All» Molecular Weight: The calculated MW is 177 kDa; however, the observed MW is 70 kDa. A splice variant of SUR1/2 has been reported at 70 kDA. (Pu et al, 2008). View All» Epitope: Cytoplasmic Domain View All» Immunogen: KLH-conjugated linear peptide of rat SUR1. View All» Background Information: The protein encoded by the SUR1 gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. The SUR1 protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is thought to form ATP-sensitive potassium channels in cardiac, skeletal, and smooth muscle (both vascular and non-vascular). No disease has been associated with this gene thus far. View All» Species Reactivity:

• Mouse

• Rat
  View All» Species Reactivity Note: Proven to react with rat. Predicted to react with mouse based on 100% sequence homology. View All» Control: Rat P1 Heart lysate View All» Quality Assurance: Evaluated by Western Blot in rat P1 lysate.Western Blot Analysis: 1 µg/mL of this antibody detected SUR1 in 10 µg of rat P1 Heart lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH7.4) 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q09428 View All» Entrez Gene Number: NP_037171.2 View All» Gene Symbol:
  • ABC36

  • HHF1

  • HI

  • HRINS

  • MRP8

  • PHHI

  • SUR

  • SUR1

  • TNDM2
    View All» Alternate Names:
    • ATP-binding cassette, sub-family C (CFTR/MRP), member 8

    • ATP-binding cassette, sub-family C, member 8

    • Sulfonylurea receptor 1

    • sulfonylurea receptor (hyperinsulinemia)
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: binds sulfonylurea; subunit of the ATP-sensitive potassium channel K(ATP), which is composed of Sur1 and the inwardly rectifying K(+) channel subunit, Kir6.2 [RGD]. View All» UniProt Summary: FUNCTION: Putative subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K+ channels and insulin release.SUBUNIT STRUCTURE: Associates with KCNJ11.SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. INVOLVEMENT IN DISEASE: Defects in ABCC8 are a cause of leucine-induced hypoglycemia (LIH) [MIM:240800]; also called leucine-sensitive hypoglycemia of infancy. LIH is a rare cause of hypoglycemia and is described as a condition in which symptomatic hypoglycemia is provoked by high protein feedings. Hypoglycemia is also elicited by administration of oral or intravenous infusions of a single amino acid, leucine. Defects in ABCC8 are the cause of familial hyperinsulinemic hypoglycemia type 1 (HHF1) [MIM:256450]; also known as persistent hyperinsulinemic hypoglycemia of infancy (PHHI) or hyperinsulinism. HHF1 is the most common cause of persistent hypoglycemia in infancy and is due to defective negative feedback regulation of insulin secretion by low glucose levels. It causes nesidioblastosis, a diffuse abnormality of the pancreas in which there is extensive, often disorganized formation of new islets. Unless early and aggressive intervention is undertaken, brain damage from recurrent episodes of hypoglycemia may occur. Defects in ABCC8 are a cause of permanent neonatal diabetes mellitus (PNDM) [MIM:606176]; also called permanent diabetes mellitus of infancy (PDMI). PNDM is a rare form of diabetes characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy. Defects in ABCC8 are the cause of transient neonatal diabetes mellitus type 2 (TNDM2) [MIM:610374]. Neonatal diabetes is a form of diabetes mellitus defined by the onset of mild-to-severe hyperglycemia within the first months of life. Transient neonatal diabetes remits early, with a possible relapse during adolescence. Defects in ABCC8 may contribute to non-insulin-dependent diabetes mellitus (NIDDM), also known as diabetes mellitus type 2, in Northern European Caucasians.SEQUENCE SIMILARITIES: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification]Contains 2 ABC transmembrane type-1 domains.Contains 2 ABC transporter domains. View All» Product Name: Anti-SUR1 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：https://www.16ao.com/thread-152966.htm
      © Merck Millipore代理AB2241 Anti-SUR1 (rabbit polyclonal)，产品报价联系微信jinshanbio