货号：AB2255

品牌：Merck Millipore

规格：100UL

目录价：￥6127.00

市场价格：￥5207.95

会员价格：￥4901.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-GABA B Receptor R2 Antibody | AB2255 View All» Replaces: AB5394 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the C-terminus of rat GABA-B-R2. View All» Molecular Weight: Although a band is observed around the calculated molecular weight of 105 kDa, Western Blotting is not a recommened application for this antibody because the band is weak in comparison to other non-specific bands present. View All» Epitope: C-terminus View All» Immunogen: Bovine thyroglobulin-conjugated linear peptide at the C-terminus of rat GABA-B-R2. View All» Background Information: Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates 4 transcript variants. View All» Species Reactivity:

• Rat

• Human

• Bovine

• Horse

• Rhesus Macaque

• Chimpanzee

• Mouse

• Canine
  View All» Species Reactivity Note: Demonstrated to react with rat. Predicted to react with human, bovine, horse, rhesus monkey, chimpanzee, mouse, and canine based on 100% sequence homology. View All» Control: Purkinje cells in rat mid-brain region View All» Quality Assurance: Evaluated by Immunohistochemistry in Purkinje cells in rat mid-brain region.Immunohistochemistry Analysis: A 1:300 dilution of this antibody detected GABA-B-R2 in Purkinje cells in rat mid-brain region. View All» Purification Method: Unpurified View All» Presentation: Unpurified guinea pig polyclonal serum with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: O88871 View All» Entrez Gene Number: NP_113990 View All» Gene Symbol:
  • GABBR2

  • GABA-B-R2

  • GABABR2

  • GPR51

  • GPRC3B

  • Gb2

  • HG20
    View All» Alternate Names:
    • G protein-coupled receptor 51

    • G-protein coupled receptor 51

    • GABA-B receptor 2

    • gamma-aminobutyric acid (GABA) B receptor, 2

    • gamma-aminobutyric acid B receptor, 2

    • GABA-B-R2

    • GABA(B)R2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunohistochemistry

      • Western Blotting
        View All» Entrez Gene Summary: GABA-B-R2 combines with GABA-B1 to form functional GABA-B receptors; inhibits high voltage activated calcium ion channels [RGD]. View All» UniProt Summary: FUNCTION: Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.SUBUNIT STRUCTURE: Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Interacts with ATF4 via its C-terminal region. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Note: Moreover coexpression of GABA-B-R1 and GABA-B-R2 appears to be a prerequisite for maturation and transport of GABA-B-R1 to the plasma membrane.TISSUE SPECIFICITY: Expressed in brain cortex, hippocampus, medial habenula, thalamus and cerebellum. Coexpression is seen in cerebellum.DEVELOPMENTAL STAGE: Abundant in brain cortex and cerebellum throughout postnatal development whereas its expression in spinal cord gradually decreases.DOMAIN: Alpha-helical parts of the C-terminal intracellular region mediate heterodimeric interaction with GABA-B receptor 1.SEQUENCE SIMILARITIES: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. View All» Product Name: Anti-GABA B Receptor R2 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Guinea Pig View All»
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