货号：AB2256

品牌：Merck Millipore

规格：50UL

目录价：￥5974.00

市场价格：￥5077.90

会员价格：￥4779.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-GABA B Receptor R1 Antibody | AB2256 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Cat. # AB2256 recognizes GABA B Receptor R1 (GABA B R1) View All» Molecular Weight: ~100-105 kDa View All» Epitope: C-Terminus interaction w/ ATF4 View All» Immunogen: Recombinant peptide (aa 972-991: PSEPPDRLSCDGSRVHLLYK) View All» Background Information: Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates 4 transcript variants. View All» Species Reactivity:

• Rat

• Mouse

• Human
  View All» Species Reactivity Note: Proven to react with Rat, Mouse and Human. Reactivity with other species has not been determined. View All» Application Notes: Immunohistochemistry: Working dilution of 1:3,000 in free floating mouse brain tissue. View All» Control: Rat brain lysates View All» Quality Assurance: Western Blotting: 1:1,000 dilution from a previous lot detected GABA B R1 on 10µg of rat brain lysate. View All» Presentation: GST-Depleted Sera with 0.05% NaN3. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt. View All» UniProt Number: Q9Z0U4 View All» Entrez Gene Number: NP_112290.2 View All» Gene Symbol:
  • FLJ92613

  • GABA-B-R1

  • GABAB(1e)

  • GABABR1

  • GABBR1-3

  • GPRC3A

  • Gb1

  • hGB1a
    View All» Alternate Names:
    • GABA-B receptor

    • GABA-B receptor 1

    • GABAB, subunit 1c

    • gamma-aminobutyric acid (GABA) B receptor 1

    • gamma-aminobutyric acid B receptor, 1

    • seven transmembrane helix receptor
      View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry
        View All» Entrez Gene Summary: metabotropic G-protein-coupled receptor for gamma-aminobutyric acid (GABA) [RGD] View All» UniProt Summary: Function: Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.Cofactor: Calcium. Required for high affinity binding to GABA.Subunit structure: Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Interacts with the leucine zipper of the C-terminal bZIP domain of ATF4 via its C-terminal region. Interacts with JAKMIP1. Subcellular location: Cell membrane; Multi-pass membrane protein. Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Note= Moreover coexpression of GABA-B-R1 and GABA-B-R2 appears to be a prerequisite for maturation and transport of GABA-B-R1 to the plasma membrane. Colocalizes with ATF4 in hippocampal neuron dendritic membranes.Tissue specificity: Isoform 1A, isoform 1B and isoform 1C are expressed in testis, stomach, spinal cord and brain including cerebral cortical layers, pyramidal cell layers of the hippocampus, granular cell layers of the dentate gyrus, basal ganglia, cerebellum (predominantly in Purkinje cells followed by granular layer). Isoform 1B is also expressed in kidney and liver. Isoform 1D is expressed in forebrain, cerebellum, eye, kidney, and urinary bladder. Domain: Alpha-helical parts of the C-terminal intracellular region mediate heterodimeric interaction with GABA-B receptor 2. The linker region between the transmembrane domain 3 (TM3) and the transmembrane domain 4 (TM4) probably play a role in the specificity for G-protein coupling.Sequence similarities: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.Contains 2 Sushi (CCP/SCR) domains. View All» Product Name: Anti-GABA B Receptor R1 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µL View All» Format: Serum View All» Host: Guinea Pig View All»
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