货号：AB2257

品牌：Merck Millipore

规格：100Ug

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Vesicular GABA Transporter Antibody | AB2257 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Cat. # AB2257 recognizes VGAT. View All» Molecular Weight: Approx. 57 kDa View All» Epitope: C-terminus View All» Immunogen: KLH conjugated Vesicular GABA Transporter corresponding to the C-terminus. View All» Background Information: Vesicular GABA transporter (VGAT), the first vesicular amino acid transporter to be molecularly identified, differs in structure from previously cloned vesicular neurotransmitter transporters and defines a novel gene family. VGAT is highly concentrated in the nerve endings of GABAergic neurons in the brain and spinal cord but also in glycinergic nerve endings. In contrast, hippocampal mossy fiber boutons, which are glutamatergic but known to contain GABA, lack VGAT immunoreactivity. Although the great majority of nerve terminals containing GABA or glycine are immunopositive for VGAT, subpopulations of nerve endings rich in GABA or glycine appear to lack the protein. Additional vesicular transporters or alternative modes of release may therefore contribute to the inhibitory neurotransmission mediated by these two amino acids. View All» Species Reactivity: Rat View All» Species Reactivity Note: Rat. Predicted to react with human, rat and monkey. View All» Application Notes: Immunohistochemistry Analysis: 1:50 - 1:500 dilution from a previous lot detected vesiluar GABA transporter using IHC-Select Detection with HRP-DAB. View All» Control: Rat brain lysate. View All» Quality Assurance: Routinely evaluated by Western Blot on rat brain lysates.Western Blot Analysis:1:500 - 1:1,000 dilution of this lot detected vesicular GABA transporter on 10 µg of rat brain lysate. View All» Purification Method: Antigen affinity purified View All» Presentation: Rabbit polyclonal serum in buffer containing 0.1M Tris-Glycine (pH7.4) 15mM NaCl with 0.05% NaN3. View All» Storage Conditions: Stable for 1 year at 2-8ºC from date of receipt. View All» UniProt Number: Q9H598 View All» Entrez Gene Number: NM_080552.2 View All» Gene Symbol:

• OTTHUMP00000030977

• VGAT

• VIAAT

• bA122O1.1

• hVIAAT
  View All» Alternate Names:
  • GABA and glycine transporter

  • Solute carrier family 32 member 1

  • Vesicular GABA transporter

  • solute carrier family 32 (GABA vesicular transporter), member 1

  • solute carrier family 32, member 1

  • vesicular inhibitory amino acid transporter
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry
      View All» Entrez Gene Summary: The protein encoded by this gene is an integral membrane protein involved in gamma-aminobutyric acid (GABA) and glycine uptake into synaptic vesicles. The encoded protein is a member of amino acid/polyamine transporter family II. [provided by RefSeq] View All» UniProt Summary: FUNCTION: Involved in the uptake of GABA and glycine into the synaptic vesicles.SUBCELLULAR LOCATION:Cytoplasmic vesicle membrane; Multi-pass membrane proteinBy similarity. TISSUE SPECIFICITY: Retina. Expressed throughout the horizontal cells or more specifically at the terminals. Ref.5SEQUENCE SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family. View All» Product Name: Anti-Vesicular GABA Transporter View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Serum View All» Host: Rabbit View All»
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