货号：AB2261

品牌：Merck Millipore

规格：100Ug

目录价：￥6127.00

市场价格：￥5207.95

会员价格：￥4901.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Tbr1 Antibody | AB2261 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Tbr1. View All» Molecular Weight: ~ 68 kDa is observed; however, UniProtKB/Swiss-Prot entry Q64336 (TBR1_MOUSE) lists a mass of 73.941 kDa. View All» Epitope: Internal View All» Immunogen: KLH-conjugated linear peptide corresponding to mouse Tbr1. View All» Background Information: Tbr1 gene is a member of a conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Tbr1, a putative transcription factor known to be expressed in post-mitotic neurons, has been found highly expressed in glutamatergic early-born cortical neurons. A similar protein has been disrupted in mice and shown to be critical for early cortical development, and causes loss of projection neurons in the olfactory bulbs and olfactory cortex. The C-terminal region the Tbr1 derived protein was found to be necessary and sufficient for association with the guanylate kinase domain of calcium/calmodulin-dependent serine protein kinase. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Horse

• Pig

• Opossum

• Bovine

• Canine
  View All» Species Reactivity Note: Proven to react with human, mouse, and rat. Predicted to react with horse, pig, opossum, bovine, and canine based on 100% sequence homology. View All» Application Notes: Immunohistochemistry Analysis: 1:100 dilution from a previous lot detected Tbr1 in mouse frontal cortex tissue. View All» Control: Human fetal brain tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human fetal brain tissue lysate.Western Blot Analysis: 0.025 µg/ml of this antibody detected Tbr1 on 10 µg of human fetal brain tissue lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified chicken polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q64336 View All» Entrez Gene Number: NP_033348 View All» Gene Symbol:
  • Tbr1

  • T-brain-1

  • TBR-1

  • TES-56
    View All» Alternate Names: T-box, brain, 1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry
      View All» UniProt Summary: FUNCTION: Probable transcriptional regulator involved in developmental processes. TBR1 is required for normal brain development.SUBCELLULAR LOCATION: Nucleus Potential. TISSUE SPECIFICTY: Expressed in specific lamina in the developing and adult brain.DEVELOPMENTAL STAGE: First detected around day 10 of embryonic development in the preplate, at day 12.5, in the cortical plate and intermediate zone, and from day 16.5 to 18.5, in a rostro-caudal gradient in the subplate. In the thalamus, expression is first observed at postnatal stage, P7, and weak expression continues in later postnatal and adult stages.SEQUENCE SIMILARITIES: Contains 1 T-box DNA-binding domain. View All» Product Name: Anti-Tbr1 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Target / Localization: Nucleus View All» Format: Affinity Purified View All» Host: Chicken View All»
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