货号：AB2267

品牌：Merck Millipore

规格：100Ug

目录价：￥5820.00

市场价格：￥4947.00

会员价格：￥4656.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-LCN2 Antibody | AB2267 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes LCN2. View All» Molecular Weight: LCN2 band observed at 25 kDa. Heavy concentration of tissue lysate and a 5 minute exposure time were used to generate the band of interest. View All» Epitope: Mature chain View All» Immunogen: KLH-conjugated linear peptide corresponding to the mature chain of human LCN2. View All» Background Information: LCN2 (also known as Neurophil Gelatinase-Associated Lipocalin or NGAL) belongs to a superfamily of lipocalins, a collection of small, diversely functional, extracellular proteins. NGAL is secreted from neutrophil granules in three different forms; a monomer of 25 kDa, a disulfide-linked homodimer at 46 kDa, and a disulfide-linked heterodimer with MMP-9 at 135-kDa. It is widely known to induce development of kidney epithelia, to bind and traffic iron, and to act as a molecular signal under inflammatory conditions, such as Crohn’s Disease. Multiple carcinoma studies have also shown elevated expression levels of LCN2 in several different human tumors affecting such organs as: colon, lung, breast, ovaries and pancreas. Additionally, there has been great interest in this protein as a possible marker for: onset of Acute Kidney Injury following cardiac surgery, the progression of Chronic Kidney Disease (CKD), and the survival chances of patients with Chronic Heart Failure (CHF). View All» Species Reactivity:

• Human

• Mouse

• Bovine

• Rat
  View All» Species Reactivity Note: Demonstrated to react with human. Predicted to react with mouse, bovine, and rat based on 100% sequence homology. View All» Application Notes: Immunohistochemistry Analysis: A 1:200 dilution of Anti-LCN2 antibody from a previous lot detected LCN2 in human spleen tissue. View All» Control: Human kidney tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human kidney tissue lysate.Western Blot Analysis: 5 µg/mL of this antibody detected LCN2 in 10 µg of human kidney tissue lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P80188 View All» Entrez Gene Number: NP_005555 View All» Gene Symbol:
  • NGAL

  • 24p3

  • p25

  • MSFI

  • HNL

  • LCN2
    View All» Alternate Names:
    • lipocalin 2

    • migration-stimulating factor inhibitor

    • siderocalin

    • Oncogene 24p3

    • 25 kDa alpha-2-microglobulin-related subunit of MMP-9

    • lipocalin 2 (oncogene 24p3)

    • neutrophil gelatinase-associated lipocalin

    • Lipocalin-2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry
        View All» UniProt Summary: FUNCTION: Transport of small lipophilic substances Potential.SUBUNIT STRUCTURE: Forms a covalently linked, disulfide-bridged heterodimer with the 92 kDa type V collagenase (MMP-9).SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Expressed in bone marrow and in tissues that are prone to exposure to microorganism. High expression is found in bone marrow as well as in uterus, prostate, salivary gland, stomach, appendix, colon, trachea and lungs. Not found in the small intestine or peripheral blood leukocytes. SEQUENCE SIMILARITIES: Belongs to the calycin superfamily. Lipocalin family. View All» Product Name: Anti-LCN2 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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