货号：AB2268

品牌：Merck Millipore

规格：

目录价：￥4264.00

市场价格：￥3624.40

会员价格：￥3411.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-CALHM1 Antibody | AB2268 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~38 kDa observed View All» Epitope: Unknown View All» Immunogen: KLH-conjugated linear peptide corresponding to human CALHM1. View All» Background Information: Calcium homeostasis modulator protein 1 (CALHM1) is a multi-pass membrane protein localized in both the cell membrane and membrane of the endoplasmic reticulum and is a member of the FAM26 family of proteins. CALHM1 has been shown to be a Ca2+ dependent regulator for the proteolysis of amyloid precurser protein (APP) as well as the peptide levels of aggregated amyloid belta (Abeta). It is also involved in mediating the concentration and permeability of cytosolic calcium. Additionally, it is thought to have a role as a pore-forming ion channel. Expression of CALHM1 is mainly found in adult brain tissue and has also been reported in retinoic acid-differentiated SH-SY5Y cells. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Canine

• Ox
  View All» Species Reactivity Note: Demonstrated to react with human. Predicted to react with mouse, rat, canine, and ox based on 100% sequence homology. View All» Application Notes: Western Blot (Snap i.d.®) Analysis: 0.5 µg/mL of this antibody from a previous lot detected CALHM1 on 10 µg of human liver tissue lysate.Immunohistochemistry Analysis: 1:50 dilution of this antibody from a previous lot detected CALHM1 in normal human brain and liver tissues. View All» Control: Human liver tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human liver tissue lysate.Western Blot Analysis: 0.1 µg/mL of this antibody detected CALHM1 on 10 µg of human liver tissue lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q8IU99 View All» Entrez Gene Number: NP_001001412 View All» Gene Symbol:
  • CALHM1

  • FAM26C
    View All» Alternate Names:
    • calcium homeostasis modulator 1

    • calcium homeostasis modulator protein 1

    • family with sequence similarity 26, member C

    • Protein FAM26C
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry (Paraffin)
        View All» Entrez Gene Summary: This gene encodes a calcium channel that plays a role in processing of amyloid-beta precursor protein. A polymorphism at this locus has been reported to be associated with susceptibility to late-onset Alzheimer's disease in some populations, but the pathogenicity of this polymorphism is unclear. View All» UniProt Summary: FUNCTION: May be a pore-forming ion channel. Controls cytosolic Ca2+ permeability and cytosolic Ca2+ concentration. Controls amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca2+ dependent manner. SUBUNIT STRUCTURE: Homooligomer; homomultimerized to form dimeric and possibly tetrameric structures. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note: Colocalizes with HSPA5 at the endoplasmic reticulum. TISSUE SPECIFICTY: Predominantly expressed in adult brain. Detected also in retinoic acid-differentiated SH-SY5Y cells. POLYMORPHISM: Leu-86 causes a dysregulation of Ca2+ homeostasis and amyloid precursor protein (APP) metabolism, and may be a risk factor for the development of Alzheimer's disease.SEQUENCE SIMILARITIES: Belongs to the FAM26 family. View All» Product Name: Anti-CALHM1 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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