货号：AB2269

品牌：Merck Millipore

规格：

目录价：￥4165.00

市场价格：￥3540.25

会员价格：￥3332.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Leukocyte immunoglobulin-like receptor 3 Antibody | AB2269 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~75 kDa observed and 69 kDa is calculated. View All» Epitope: 0 View All» Immunogen: KLH-conjugated linear peptide corresponding to human Leukocyte immunoglobulin-like receptor 3. View All» Background Information: Leukocyte immunoglobulin-like receptor 3 is a member of the LILR family which includes stimulatory cell-surface immunoregulatory receptors and dampening cell-surface receptors. It associates with MHC class I molecules on the cell surface to regulate osteoclast formation. This protein could be a novel target to control inflammatory arthritis and certain skeletal system disorders. Leukocyte immunoglobulin-like receptor 3 has been found to be upregulated on the cell surface in HIV-1 patients called elite controllers. These patients maintain undetectable levels of HIV-1 without any antiretroviral treatment. View All» Species Reactivity:

• Mouse

• Human

• Chimpanzee
  View All» Species Reactivity Note: Demonstrated to react with human and mouse. Predicted to react with chimpanzee based on 100% sequence homology. View All» Application Notes: Flow Cytometry Analysis: 1 µg of this antibody detected Leukocyte immunoglobulin-like receptor 3 in Jurkat cells. View All» Control: Jurkat cell lysate View All» Quality Assurance: Evaluated by Western Blot in Jurkat cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected Leukocyte immunoglobulin-like receptor 3 on 10 µg of Jurkat cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O75022 View All» Entrez Gene Number: NP_006855 View All» Gene Symbol:
  • ILT-5

  • LIR3

  • CD85a

  • ILT5

  • LIR-3

  • PIRB

  • HL9

  • CD85A

  • LILRB3
    View All» Alternate Names:
    • leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3

    • Leukocyte immunoglobulin-like receptor 3

    • leukocyte immunoglobulin-like receptor subfamily B member 3

    • Monocyte inhibitory receptor HL9

    • Immunoglobulin-like transcript 5

    • CD85a antigen

    • CD85 antigen-like family member A
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Flow Cytometry
        View All» Entrez Gene Summary: This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: May act as receptor for class I MHC antigens.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICTY: Detected in monocytes and B-cells. DOMAIN: Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.MISCELLANEOUS: Belongs to the leukocyte receptor cluster (LRC) present on 19q13.4.SEQUENCE SIMILARITIES: Contains 4 Ig-like C2-type (immunoglobulin-like) domains. View All» Product Name: Anti-Leukocyte immunoglobulin-like receptor 3 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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