货号：AB2270

品牌：Merck Millipore

规格：EA

目录价：￥3828.00

市场价格：￥3253.80

会员价格：￥3062.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-LRP-4 Antibody | AB2270 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes LRP-4 at the cytoplasmic domain. View All» Molecular Weight: 212 kDa calculated. It has been reported that transfection of LRP-4 reveals different protein products at 20 kDa, 75 kDa and 250 kDa. While the 250 kDa band represents full length LRP-4, the two smaller bands appear to be processing products of the receptor. No bands were detected in the untransfected conditions. (Dietrich, M.F., et al. (2010). PLoS ONE 5(4):e9960:1-7.) View All» Epitope: Cytoplasmic domain View All» Immunogen: KLH-conjugated linear leptide corresponding to human LRP-4 at the cytoplasmic domain. View All» Background Information: Low-density lipoprotein receptor-related protein 4 (LRP-4) is a novel, single-pass type I membrane protein belonging to the LDLR family and is comprised of three EGF-like domains, eight LDL-receptor class A domains, and twenty LDL-receptor class B repeats. The exact function of LRP-4 has yet to be elucidated, however it is thought to function as a cell surface receptor with the ability to both bind and neutralize extracellular ligands, internalizing them for lysosomal degradation. Expression has been observed in various regions of the brain. View All» Species Reactivity:

• Human

• Rat

• Ox

• Horse

• Rhesus Macaque
  View All» Species Reactivity Note: Demonstrated to react with human and mouse. Predicted to react with ox, equine, and rhesus monkey based on 100% sequence homology. Other homologies: Rat (92% sequence homology). View All» Application Notes: Immunohistochemistry Analysis: 1:500 dilution of this antibody from a previous lot detected LRP-4 in normal rat brain tissue. View All» Control: Normal human brain tissue View All» Quality Assurance: Evaluated by Immunohistochemistry in normal human brain tissue.Immunohistochemistry Analysis: 1:500 dilution of this antibody detected LRP-4 in normal human brain tissue. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O75096 View All» Entrez Gene Number: NP_002325 View All» Gene Symbol:
  • LRP4

  • LRP-4

  • LRP10

  • MEGF7
    View All» Alternate Names:
    • low density lipoprotein receptor-related protein 4

    • Multiple epidermal growth factor-like domains 7

    • low-density lipoprotein receptor-related protein 4
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Immunohistochemistry (Paraffin) View All» Entrez Gene Summary: This gene encodes a member of the low-density lipoprotein receptor-related protein family. The encoded protein may be a regulator of Wnt signaling. Mutations in this gene are associated with Cenani-Lenz syndrome. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Potential cell surface endocytic receptor, which binds and internalizes extracellular ligands for degradation by lysosomes.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein Potential. TISSUE SPECIFICTY: Expressed in several regions of the brain.SEQUENCE SIMILARITIES: Belongs to the LDLR family.Contains 3 EGF-like domains.Contains 8 LDL-receptor class A domains.Contains 20 LDL-receptor class B repeats.SEQUENCE CAUTION: The sequence BAE19679.1 differs from that shown. Reason: Erroneous initiation. View All» Product Name: Anti-LRP-4 View All» Concentration: 0.50 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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