货号：AB2271

品牌：Merck Millipore

规格：EA

目录价：￥3588.00

市场价格：￥3049.80

会员价格：￥2870.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Tid1 Antibody | AB2271 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Tid1 at the J domain. View All» Molecular Weight: ~40 kDa View All» Epitope: J domain View All» Immunogen: KLH-conjugated linear peptide corresponding to human Tid1 at the J domain. View All» Background Information: Tumorous imaginal disc 1 (Tid1) is a regulatory protein, comprised of a CR-type zinc finger and a J domain, belonging to DnaJ family of cochaperones/specificity factors for the Hsp70 family. Tid1 is involved in regulating several cellular processes such as cell proliferation, induction of apoptosis, and cell survival. Although mainly localized to mitochondria, most of the functions performed by Tid1 are nonmitochondrial. Tid1 induces the release of mitochondrial cytochrome C and activates caspase 3. In humans, Tid1 expression produces two splice variant isoforms that each serve a contrasting role in apoptotic regulation; Tid1-L (43 kDa) upregulates apoptosis in response to either mytomyocin C or TNF, and Tid1-S (40 kDa) serves to suppress apoptotic activity. The highest levels of expression have been observed in the liver, lung, heart and skeletal muscle, as well as in keratinocytes. Originally, it was described as interacting with the HPV E7 oncoprotein. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Bovine

• Chimpanzee

• Canine

• Rhesus Macaque
  View All» Species Reactivity Note: Demonstrated to react with human. Predicted to react with mouse, rat, equine, bovine, chimpanzee, canine, and rhesus macaque based on 100% sequence homology. View All» Application Notes: Immunohistochemistry Analysis: a 1:500 dilution of this antibody from a previous lot detected Tid1 in human skin and uterine cancer tissue. View All» Control: SK-BR3 cell lysate View All» Quality Assurance: Evaluated by Western Blot in SK-BR3 cell lysate.Western Blot Analysis: 0.1 µg/mL of this antibody detected Tid1 on 10 µg of SK-BR3 cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q96EY1 View All» Entrez Gene Number: Q96EY1 View All» Gene Symbol:
  • TID1

  • hTid-1

  • FLJ45758

  • HCA57
    View All» Alternate Names:
    • DnaJ (Hsp40) homolog, subfamily A, member 3

    • DnaJ protein Tid-1

    • Tumorous imaginal discs protein Tid56 homolog

    • Hepatocellular carcinoma-associated antigen 57

    • dnaJ homolog subfamily A member 3, mitochondrial

    • tumorous imaginal discs homolog
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry
        View All» UniProt Summary: FUNCTION: Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity.SUBUNIT STRUCTURE: Interacts with JAK2, HSPA9B and IFN-gammaR2 chain. Interacts with Ras GTPase-activating protein 1 (RASA1). SUBCELLULAR LOCATION: Mitochondrion matrix. TISSUE SPECIFICITY: Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also expressed in keratinocytes. DOMAIN: Modulation of apoptosis, i.e proapoptotic activity of isoform 1 and antiapoptotic activity of isoform 2, is J domain-dependent.PTM: Tyrosine phosphorylated By similarity. Phosphorylated upon DNA damage, probably by ATM or ATR. SEQUENCE SIMILARITIES: Contains 1 CR-type zinc finger.Contains 1 J domain.SEQUENCE CAUTION: The sequence AAF66245.1 differs from that shown. Reason: Frameshift at positions 408 and 411. The sequence AAH12343.1 differs from that shown. Reason: Erroneous initiation. View All» Product Name: Anti-Tid1 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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