货号：AB2280

品牌：Merck Millipore

规格：

目录价：￥3861.00

市场价格：￥3281.85

会员价格：￥3088.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Neurotrimin Antibody | AB2280 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Neurotrimin at the Ig-like C2-type 3 domain. View All» Molecular Weight: ~ 35/58 kDa observed. UniProtKB/Swiss-Prot Q9P121 (NTRI_HUMAN) describes 3 isoforms produced by alternative splicing. A non-specific band appears at 50 kDa.UniProtKB/Swiss-Prot Q9P121 (NTRI_HUMAN) describes 3 isoforms produced by alternative splicing: Isoform 1 at 38 kDa, Isoform 2 at 38 kDa, Isoform 3 at 35 kDa. A glycosylated isoform ~ 58kDa is also reported in literature (Krizsan-Agbas, 2008). View All» Epitope: Ig-like C2-type 3 domain View All» Immunogen: KLH-conjugated linear peptide corresponding to the Ig-like C2-type 3 domain of human Neurotrimin. View All» Background Information: Neurotrimin (Ntm) is a cell adhesion molecule that along with opiod-binding cell adhesion molecule (OBCAM) and limbic system-associated membrane protein (LAMP) comprises the IgLON family of neural cell adhesion molecules. Ntm has been shown to have roles in mediating neurite outgrowth, in constructing noncovalent homodimers within the membrane plane, and in advancing cell adhesion via a homophilic process. Recent studies have also indicated Neurotrimin's potential role in regulating estrogen-induced degeneration of some peripheral, sympathetic axon targets. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Primate

• Chimpanzee

• Rhesus Macaque
  View All» Species Reactivity Note: Demonstrated to react with human, mouse, and rat. Predicted to react with primate, chimpanzee, and rhesus monkey based on 100% sequence homology. View All» Application Notes: Immunohistochemistry Analysis: 1:500 dilution from a previous lot detected Neurotrimin in human neurons of the limbic cortex tissue. View All» Control: Human fetal brain tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human fetal brain tissue lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected Neurotrimin on 10 µg of human fetal brain tissue lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9P121 View All» Entrez Gene Number: NP_057606 View All» Gene Symbol:
  • IGLON2

  • HNT

  • NT

  • NTM

  • NTRI

  • hNT3
    View All» Alternate Names:
    • neurotrimin

    • IgLON family member 2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry (Paraffin)
        View All» Entrez Gene Summary: This gene encodes a member of the IgLON (LAMP, OBCAM, Ntm) family of immunoglobulin (Ig) domain-containing glycosylphosphatidylinositol (GPI)-anchored cell adhesion molecules. The encoded protein may promote neurite outgrowth and adhesion via a homophilic mechanism. This gene is closely linked to a related family member, opioid binding protein/cell adhesion molecule-like (OPCML), on chromosome 11. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Neural cell adhesion molecule.SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor › GPI-anchor. SEQUENCE SIMILARITIES: Belongs to the immunoglobulin superfamily. IgLON family.Contains 3 Ig-like C2-type (immunoglobulin-like) domains. View All» Product Name: Anti-Neurotrimin View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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