货号：AB2290

品牌：Merck Millipore

规格：100Ug

目录价：￥5513.00

市场价格：￥4686.05

会员价格：￥4410.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MAP-2 Antibody | AB2290 View All» Replaces: AB5622 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes MAP-2. View All» Molecular Weight: ~260 kDa observed. Isoform MAP2x can be observed at ~202 kDa and isoform MAP2b can be observed at ~199 kDa. View All» Immunogen: Three KLH-conjugated linear peptides corresponding to the N-terminal and central regions of rat MAP-2 . View All» Background Information: The microtubule-associated protein 2 (MAP-2) is an abundant neuronal cytoskeletal protein that binds to tubulin and stabilizes microtubules. (Herzog and Weber, 1978). MAP-2 is essential for the development and maitenance of neuronal morphology (Matus, 1991). Three primary isoforms of MAP-2, the high molecular weight MAP2a and MAP2b, and the low molecular weight MAP2c (resulting from alternate splicing of the MAP2 gene), have been identified in neurons. (Chung et al., 1996). The low molecular weight isoform, MAP2c, is expressed in developing brain and is down-regulated during brain maturation, whereas the high molecular weight MAP2b is expressed in both developing and adult brain. The MAP2a appears only after brain maturation (Tucker, 1990). All these forms bind to microtubules through a domain near the carboxyl terminus that contains either three or four similar repeats of a 31-amino-acid motif (Lewis et al., 1988). MAP-2 together with MAP-4 and tau proteins belong to the family of thermostable proteins associated with microtubules. View All» Species Reactivity: Rat View All» Species Reactivity Note: Demonstrated to react with rat. Other homologies: Mouse (94% sequence homology). Human (72% sequence homology). View All» Application Notes: Immunohistochemistry Analysis: 1:200 dilution from a previous lot detected MAP-2 in rat brain tissue. View All» Control: Rat brain microsomal tissue lysate View All» Quality Assurance: Evaluated by Western Blot in rat brain microsomal tissue lysate.Western Blot Analysis: 0.1 µg/mL of this antibody detected MAP-2 on 10 µg of rat brain microsomal tissue lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P15146 View All» Entrez Gene Number: NP_037198 View All» Gene Symbol:

• MAP2

• MAP2B

• MAP-2

• MAP2C

• MAP2A
  View All» Alternate Names:
  • microtubule-associated protein 2

  • MAP2

  • MAP 2
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry (Paraffin)
      View All» Entrez Gene Summary: Regulates and organizes microtubules; may serve as a scaffolding protein for neuromodulatory activities [RGD]. View All» UniProt Summary: FUNCTION: The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.SUBCELLULAR LOCATION: Cytoplasm › cytoskeleton Probable. DEVELOPMENTAL STAGE: Isoform MAP2C is expressed during embryonic brain development and until postanatal day 10. Isoform MAP2B is expressed throughout brain development.PTM: Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity). MAP2A/c is phosphorylated. SEQUENCE SIMILARITIES: Contains 4 Tau/MAP repeats. View All» Product Name: Anti-MAP-2 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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