货号：AB2290B

品牌：Merck Millipore

规格：

目录价：￥5096.00

市场价格：￥4331.60

会员价格：￥4076.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MAP-2 Antibody, Biotin Conjugate | AB2290B View All» Promotional Text: Special Offer on Antibodies! Click Here! View All» Molecular Weight: The unconjugated parent antibody (Cat. No. AB2290) has an observed molecular weight at ~260 kDa. View All» Immunogen: KLH-conjugated linear peptide corresponding to rat MAP-2. View All» Background Information: The microtubule-associated protein 2 (MAP-2) is an abundant neuronal cytoskeletal protein that binds to tubulin and stabilizes microtubules. (Herzog and Weber, 1978). MAP-2 is essential for the development and maitenance of neuronal morphology (Matus, 1991). Three primary isoforms of MAP-2, the high molecular weight MAP2a and MAP2b, and the low molecular weight MAP2c (resulting from alternate splicing of the MAP2 gene), have been identified in neurours. (Chung et al., 1996). The low molecular weight isoform, MAP2c, is expressed in developing brain and is down-regulated during brain maturation, whereas the high molecular weight MAP2b is expressed in both developing and adult brain. The MAP2a appears only after brain maturation (Tucker, 1990). All these forms bind to microtubules through a domain near the carboxyl terminus that contains either three or four similar repeats of a 31-amino-acid motif (Lewis et al., 1988). MAP-2 together with MAP-4 and tau proteins belong to the family of thermostable proteins associated with microtubules. View All» Species Reactivity:

• Rat

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with Rat and Mouse. View All» Application Notes: Immunohistochemistry Analysis: A 1:100 dilution from a representative lot detected MAP-2 in paraffin sections of adult mouse brain tissue. View All» Control: Adult mouse brain tissue View All» Quality Assurance: Evaluated by Immunohistochemistry in adult mouse brain tissue.Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected MAP-2 in cryosections of adult mouse brain tissue. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal conjugated to Biotin in PBS with 0.1% sodium azide and 15 mg/mL BSA.. View All» Storage Conditions: Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt. View All» UniProt Number: P15146 View All» Entrez Gene Number: NP_037198 View All» Gene Symbol:
  • Map2

  • Mtap2
    View All» Alternate Names:
    • Microtubule-associated protein 2

    • MAP-2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Immunohistochemistry View All» Entrez Gene Summary: Regulates and organizes microtubules; may serve as a scaffolding protein for neuromodulatory activities [RGD]. View All» UniProt Summary: FUNCTION: The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.SUBCELLULAR LOCATION: Cytoplasm › cytoskeleton Probable. DEVELOPMENTAL STAGE: Isoform MAP2C is expressed during embryonic brain development and until postanatal day 10. Isoform MAP2B is expressed throughout brain development.PTM: Phosphorylated upon DNA damage, probably by ATM or ATR By similarity. MAP2A/c is phosphorylated.SEQUENCE SIMILARITIES: Contains 4 Tau/MAP repeats. View All» Product Name: Anti-MAP-2, Biotin Conjugate View All» Qty/Pk: 100 µL View All» Format: Biotin View All» Host: Rabbit View All»
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