货号：AB2298

品牌：Merck Millipore

规格：

目录价：￥4621.00

市场价格：￥3927.85

会员价格：￥3696.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-BMAL1 Antibody | AB2298 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Cat. # AB2298 recognizes the internal domain of BMAL1. View All» Molecular Weight: ~70 kDa View All» Epitope: Internal Domain View All» Immunogen: KLH conjugated synthetic linear peptide corresponding to the internal domain of BMAL1. View All» Background Information: Brain and muscle Arnt-like protein-1 (BMAL1; also known as MOP3 or Arnt3) is a transcription factor known to regulate circadian rhythm. BMAL1 is the only component of the mammalian circadian clock whose sole deletion in a mouse model generates arrhythmicity. In addition to defects in the clock, these BMAL1 null-mice also have reproductive problems are small in stature, age quickly and have progressive arthropathy that results in having less overall locomotor activity than wild type mice. Recent phenotyping data suggests that BMAL1 and its partner Clock also play a role in regulation of glucose homeostasis and metabolism. Finally, BMAL1, NPAS2, and PER2 have been associated with seasonal affective disorder in humans. BMAL1 transcription is circadian and reciprocally regulated by NR1D1 (Rev-erb-alpha) and RORA, which establishes a second interlocking loop in the mammalian circadian clock. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Opossum

• Bovine

• Primate

• Monkey
  View All» Species Reactivity Note: Human. May react with mouse, rat, opossum, bovine, primate and monkey. Based on sequence homology. Reactivity with other species has not been determined. View All» Control: HeLa nuclear extract tissue lysate. View All» Quality Assurance: Western Blot: 1:5000 dilution detected BMAL1 on 10 μg of HeLa nuclear extract. View All» Purification Method: Antigen affinity purified View All» Presentation: Purified rabbit polyclonal antibody in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3. View All» Storage Conditions: Stable for 1 year at 2-8ºC from date of receipt. View All» UniProt Number: O00327 View All» Entrez Gene Number: NP_001075390.1 View All» Alternate Names:
  • Aryl hydrocarbon receptor nuclear translocator-like protein 1

  • Brain and muscle ARNT-like 1

  • Member of PAS protein 3

  • Basic-helix-loop-helix-PAS protein MOP3

  • bHLH-PAS protein JAP3
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: Function: ARNTL-CLOCK heterodimers activate E-box element (3'-CACGTG-5') transcription of a number of proteins of the circadian clock. This transcription is inhibited in a feedback loop by PER, and also by CRY proteins By similarity.Subunit structure: Component of the circadian clock oscillator which includes the CRY proteins, CLOCK or NPAS2, ARNTL or ARNTL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Efficient DNA binding requires dimerization with another bHLH protein. Heterodimerization with CLOCK is required for E-box-dependent transactivation, for CLOCK nuclear translocation and degradation, and, for phosphorylation of both CLOCK and ARNTL. Interaction with PER and CRY proteins requires translocation to the nucleus. Interaction of the CLOCK-ARNTL heterodimer with PER or CRY inhibits transcription activation. Interacts with HSP90; with AHR in vitro, but not in vivo By similarity.Subcellular location: NucleusPost-translational modification: Acetylated on Lys-544 upon dimerization with CLOCK. Acetylation facilitates CRY1- mediated repression.Phosphorylated upon dimerization with CLOCK. Ref.5 Ref.6Sumoylated on Lys-266 upon dimerization with CLOCK. Ref.7Sequence similarities: Contains 1 basic helix-loop-helix (bHLH) domain.Contains 1 PAC (PAS-associated C-terminal) domain.Contains 2 PAS (PER-ARNT-SIM) domains. View All» Product Name: Anti-BMAL1 Antibody | AB2298 View All» Concentration: 1 mg/mL. View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
    © 金山科研平台是专业的授权总代理区域代理经销平台。
    © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
    © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
    © 本文地址：https://www.16ao.com/thread-153053.htm
    © Merck Millipore代理AB2298 ANTI-BMAL1，产品报价联系微信jinshanbio