货号：AB2959

品牌：Merck Millipore

规格：100Ug

目录价：￥5513.00

市场价格：￥4686.05

会员价格：￥4410.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-ADAM 9 Antibody, disintegrin domain | AB2959 View All» Replaces: AB19025 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~ 90 kDa observed. 2 isoforms are produced by alternative splicing: Isoform 1 at 91 kDa and Isoform 2 at 72 kDa. View All» Epitope: disintegrin domain View All» Immunogen: KLH-conjugated linear peptide corresponding to the disintegrin domain of human ADAM 9. View All» Background Information: A disintegrin and metalloproteinase domain-containing protein 9 (ADAM 9) belongs to a family of transmembrane, membrane-anchored, disintegrin-containing proteins that are involved in several biological functions such as protein ectodomain shedding, cell fusion, and cell adhesion. ADAMs contain several characteristic domains, two of which, the protease and disintegrin domains, are noted for their homology to snake venom metalloprotease. The exact function of ADAM 9 is yet unknown, however it is widely distributed, is found within keratinocytes, and is ideally placed on the cell membrane, which some studies have suggested supports a role in cell migration and motility. Alternative splicing results in two isoforms; isoform 1 is found within the cell membrane and is considered a single-pass type 1 membrane protein, while isoform 2 is secreted. Mutations in ADAM 9 expression are causal to cone-rod dystrophy type 9 or CORD9 which is characterized by visible retinal pigment deposits and loss of cone photoreceptors leading and rod degeneration, ultimately resulting in severe loss of vision. View All» Species Reactivity:

• Human

• Primate

• Chimpanzee
  View All» Species Reactivity Note: Demonstrated to react with human. Predicted to react with primate and chimpanzee based on 100% sequence homology. Mouse and rat (90% sequence homology). View All» Control: Human chondrocyte cell lysate View All» Quality Assurance: Evaluated by Western Blot in human chondrocyte cell lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected ADAM 9 in 10 µg of human chondrocyte cell lysate. View All» Purification Method: Protein A purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine, pH 7.4, 150 mM NaCl, with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q13443 View All» Entrez Gene Number: NP_003807 View All» Gene Symbol:
  • ADAM9

  • Mltng

  • MDC9

  • ADAM12

  • MCMP

  • MCMP-PEN

  • MLTNG

  • Meltrin-gamma
    View All» Alternate Names:
    • ADAM metallopeptidase domain 9 (meltrin gamma)

    • a disintegrin and metalloproteinase domain 9 (meltrin gamma)

    • Cellular disintegrin-related protein

    • Myeloma cell metalloproteinase

    • Metalloprotease/disintegrin/cysteine-rich protein 9
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Two alternative splice variants have been identified, encoding distinct isoforms. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Probable zinc protease. May mediate cell-cell or cell-matrix interactions. Isoform 2 displays alpha-secretase activity for APP.COFACTOR: Binds 1 zinc ion per subunit (Probable).SIZE: 819 amino acids; 90556 Da SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein. & Isoform 2: Secreted.TISSUE SPECIFICITY: Widely expressed. Expressed in chondrocytes. Highest expression of isoform 2 found in liver and heart.SIMILARITY: Contains 1 disintegrin domain. & Contains 1 EGF-like domain. & Contains 1 peptidase M12B domain. View All» Product Name: Anti-ADAM 9, disintegrin domain View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rabbit View All»
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