货号：AB2969

品牌：Merck Millipore

规格：50MIG

目录价：￥3943.00

市场价格：￥3351.55

会员价格：￥3154.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Gelsolin Antibody | AB2969 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~ 85kDa and ~ 80 kDa observed. Isoform 1 (~85 kDa) is the secreted form of the protein and Isoform 2 (~80 kDa) is the cytoplasmic form of the protein. View All» Immunogen: KLH-conjugated linear peptide corresponding to a region within the actin-binding domain of human Gelsolin. View All» Background Information: Gelsolin is a calcium-dependent actin capping and severing protein belonging to the villin/gelsolin family and serves to regulate several cellular functions: remodeling actin cytoskeleton, motility, morphology, secretion, and apoptosis. It is able to bind actin filaments and monomers at the plus end, effectively inhibiting the exchange of monomers. It is also able to sever preformed filaments and increase nucleation. When cleaved by caspase-3, the N-terminal end of gelsolin is active and pro-apoptotic, promoting the depolarization of actin and leading to cell death. However, studies have shown overepxression of gelsolin effectively inhibits caspase-3 and can therefore have a role in cell survival. Expression has been observed in fibroblasts, nonmuscle cells, phagocytic cells, platelets, skeletal and smooth muscle cells. Mutations in gelsolin expression are causal to amyloidosis type 5 (AMYL5). High levels of expression have been linked to human heart failure progression. View All» Species Reactivity:

• Human

• Canine

• Bovine
  View All» Species Reactivity Note: Demonstrated to react with human and canine. Predicted to react with bovine based on 100% sequence homology. Other homologies: Mouse and rat (95% sequence homology). View All» Application Notes: Western Blot (Snap i.d.®) Analysis: 0.5 µg/mL from a previous lot detected Gelsolin in 10 µg of MDCK cell lysate.Immunohistochemistry Analysis: 1:1,000 dilution from a previous lot detected Gesolin in human colon adenocarcinoma tissue. View All» Control: MDCK cell lysate View All» Quality Assurance: Evaluated by Western Blot in MDCK cell lysate.Western Blot Analysis: 0.5 µg/mL of the antibody detected Gelsolin in 10 µg of MDCK cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P06396 View All» Entrez Gene Number: NP_000168 View All» Gene Symbol:
  • ADF

  • GSN

  • AGEL
    View All» Alternate Names:
    • gelsolin

    • gelsolin (amyloidosis, Finnish type)

    • brevin

    • Actin-depolymerizing factor

    • Brevin
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry
        View All» Entrez Gene Summary: The protein encoded by this gene binds to the 'plus' ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed.SUBUNIT STRUCTURE: Binds to actin and to fibronectin. SUBCELLULAR LOCATION: Isoform 2: Cytoplasm › cytoskeleton. Isoform 1: Secreted. TISSUE SPECIFICTY: Phagocytic cells, platelets, fibroblasts, nonmuscle cells, smooth and skeletal muscle cells.PTM: Phosphorylation on Tyr-86, Tyr-409, Tyr-465, Tyr-603 and Tyr-651 in vitro is induced in presence of phospholipids.INVOLVEMENT IN DISEASE: Defects in GSN are the cause of amyloidosis type 5 (AMYL5) [MIM:105120]; also known as familial amyloidosis Finnish type. AMYL5 is a hereditary generalized amyloidosis due to gelsolin amyloid deposition. It is typically characterized by cranial neuropathy and lattice corneal dystrophy. Most patients have modest involvement of internal organs, but severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure.SEQUENCE SIMILARITIES: Belongs to the villin/gelsolin family.Contains 6 gelsolin-like repeats. View All» Product Name: Anti-Gelsolin View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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