货号：AB2974

品牌：Merck Millipore

规格：100Ul

目录价：￥4316.00

市场价格：￥3668.60

会员价格：￥3452.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-Myosin Heavy Chain 2A (MYH9) (Ser1943) Antibody | AB2974 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Myosin Heavy Chain 2A phosphorylated at Ser1943. View All» Molecular Weight: ~260 kDa observed. 2 isoforms are produced by alternative splicing: Isoform 1 at ~226 kDa and Isoform 2 at ~160 kDa. View All» Epitope: Phosphorylated Ser1943. View All» Immunogen: KLH-conjugated linear peptide corresponding to human Myosin Heavy Chain 2A phosphorylated at Ser1943. View All» Modifications: Phosphorylation View All» Background Information: Myosin-2A heavy chain (MYH9) phosphorylation is known to be very important in regulating cell motility and chemotaxis. The suppression of myosin-2A heavy chain expression is strongly associated with osteoclast fusion and multinucleation. Recent research indicates that modifications in the myosin-IIA heavy chain could increase the risk of kidney disease. Myosin-2A heavy chain is shown to work with WAVE2 and is localized at the leading edge of the lamellipodia formation in cells. View All» Species Reactivity:

• Human

• Rhesus Macaque
  View All» Species Reactivity Note: Demonstrated to react with Human. Predicted to react with Rhesus Macaque based on 100% sequence homology. Other homologies: Canine (91% sequence homology), Porcine (90% sequence homology), and Rat and Mouse (80% sequence homology). View All» Application Notes: Immunofluorescence Analysis: A 1:400 dilution from a representative lot detected phospho-Myosin Heavy Chain 2A (MYH9) (Ser1943) in MDA-MB-231 cells. (Image courtesy of Anne R. Bresnick, Ph.D., Albert Einstein College of Medicine).Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected phospho-Myosin Heavy Chain 2A (MYH9) (Ser1943) in MDA-MB-231 cells. (Image courtesy of Anne R. Bresnick, Ph.D., Albert Einstein College of Medicine).Western Blot Analysis: A previous lot of this antibody was used to detect phospho-Myosin Heavy Chain 2A (MYH9) (Ser1943) in conjunction with other associated proteins in multiple breast cancer cell lines. (Data courtesy of Anne R. Bresnick, Ph.D., Albert Einstein College of Medicine). View All» Control: Lambda phosphastase-untreated and lambda phosphastase-treated MDA-MB-468 cell lysates. View All» Quality Assurance: Evaluated by Western Blot in lambda phosphastase-untreated and lambda phosphastase-treated MDA-MB-468 cell lysates.Western Blot Analysis: 0.1 µg/mL of this antibody detected phospho-Myosin Heavy Chain 2A (MYH9) (Ser1943) in 10 µg of lambda phosphastase-treated MDA-MB-468 cell lysates. View All» Purification Method: Affinity Purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P35579 View All» Entrez Gene Number: NP_002464 View All» Gene Symbol: MYH9 View All» Alternate Names:
  • MHA

  • FTNS

  • EPSTS

  • DFNA17

  • NMMHCA

  • MGC104539

  • NMHC-II-A

  • MYH9

  • Myosin-9

  • Cellular myosin heavy chain, type A

  • Myosin heavy chain 9

  • Myosin heavy chain, non-muscle Iia

  • Non-muscle myosin heavy chain A

  • NMMHC-A, Non-muscle myosin heavy chain Iia

  • NMMHC II-a

  • NMMHC-IIA
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunocytochemistry

    • Immunofluorescence
      View All» Entrez Gene Summary: This gene encodes a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain. The protein is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in MYH9 are the cause of non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. View All» UniProt Summary: FUNCTION: Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.SUBUNIT STRUCTURE: Interacts with PDLIM2 By similarity. Interacts with SLC6A4 By similarity. Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with SVIL.TISSUE SPECIFICITY: In the kidney, expressed in the glomeruli. Also expressed in leukocytes. View All» Product Name: Anti-phospho-Myosin Heavy Chain 2A (MYH9) (Ser1943) View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：https://www.16ao.com/thread-153108.htm
      © Merck Millipore代理AB2974 Anti-phospho-Myosin Heavy Chain 2A (MYH9) (Ser1943) Antibody;store at +2℃ to +8℃，产品报价联系微信jinshanbio