货号：AB2971

品牌：Merck Millipore

规格：100Ug

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-LAMP-1 (CD107a) Antibody | AB2971 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: The antibody recognizes LAMP-1 at the topological domain (Lumenal). View All» Molecular Weight: ~ 95kDa observed. Although the calculated MW 45 kDa, LAMP-1 is heavily glycosylated and therefore, MW typically can be expected between 90-120 kDa. Uncharacterized bands may be observed in some lysates. View All» Epitope: Topological domain (Lumenal) View All» Immunogen: KLH-conjugated linear peptide corresponding to human LAMP-1 at the topological domain (Lumenal). View All» Background Information: Lysosome-associated membrane protein 1 (LAMP-1) is a highly glycosolated, single-pass type 1 membrane protein belonging to the lysosome- associated membrane protein family; a group of proteins that make up the majority of the lysosomal membrane and are considered crucial mediators for cellular adhesion by interacting with carbohydrate receptors. LAMP-1 functions to traffic carbohydrate ligands to selectins. It is also thought to play a role in tumor cell metastasis. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Rhesus Macaque
  View All» Species Reactivity Note: Demonstrated to react with human, mouse, and rat. Predicted to react with rhesus macaque based on 100% sequence homology. View All» Application Notes: Western Blot (Snap i.d.) Analysis: 1 µg/mL from a previous lot detected LAMP-1 in 10 µg of EL4 cell lysate.Immunocytochemistry Analysis: 1:500 dilution from a previous lot detected LAMP-1 in NIH/3T3, A431, and HeLa cells. View All» Control: EL4 cell lysate View All» Quality Assurance: Evaluated by Western Blot in EL4 cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected LAMP-1 in 10 µg of EL4 cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P11279 View All» Entrez Gene Number: NP_005552 View All» Gene Symbol:
  • LAMP1

  • LAMP-1

  • LAMPA

  • LGP120

  • CD107a
    View All» Alternate Names:
    • lysosomal-associated membrane protein 1

    • lysosome-associated membrane glycoprotein 1

    • Lysosome-associated membrane protein 1

    • CD107 antigen-like family member A

    • CD107a antigen
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry
        View All» Entrez Gene Summary: The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note: This protein shuttles between lysosomes, endosomes, and the plasma membrane.PTM: O- and N-glycosylated; some of the 18 N-linked glycans are polylactosaminoglycans. SEQUENCE SIMILARITIES: Belongs to the LAMP family. View All» Product Name: Anti-LAMP-1 (CD107a) View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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