货号：AB2988

品牌：Merck Millipore

规格：1EA

目录价：￥5264.67

市场价格：￥4474.97

会员价格：￥4211.74

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-LYVE1 Antibody | AB2988 View All» Replaces: 07-538 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes LYVE1. View All» Molecular Weight: ~ 40 kDa View All» Epitope: Unknown View All» Immunogen: KLH-conjugated linear peptide corresponding to mouse LYVE1. View All» Isotype: IgG View All» Background Information: LYVE1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves. LYVE1 may function in lymphatic hyaluronan transport. Additionally, LYVE1 has a role in tumor metastasis. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with human. Predicted to react with mouse based on 100% sequence homology. Rat (90% sequence homology). View All» Application Notes: Not recommended to work in western blot using mouse liver lysate. View All» Control: Ovarian cancer tissue View All» Quality Assurance: Evaluated by Immunohistochemistry in ovarian cancer tissue.Immunohistochemistry Analysis: 1:1,000 dilution of this antibody detected LYVE1 in ovarian cancer tissue. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q8BHC0 View All» Entrez Gene Number: NP_444477 View All» Gene Symbol:
  • LYVE1

  • CRSBP-1

  • CRSBP1

  • HARl

  • LYVE-1

  • XLKD1
    View All» Alternate Names:
    • Cell surface retention sequence-binding protein 1

    • Extracellular link domain-containing protein 1

    • Hyaluronic acid receptor

    • cell surface retention sequence binding protein-1

    • extracellular link domain containing 1

    • extracellular link domain-containing 1

    • lymphatic vessel endothelial hyaluronan receptor 1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Immunohistochemistry View All» Entrez Gene Summary: This gene encodes a type I integral membrane glycoprotein. The encoded protein acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis. View All» UniProt Summary: FUNCTION: Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as an hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes. SUBUNIT STRUCTURE: Homodimer; disulfide-linked. Interacts with PDGFB and IGFBP3. Forms a transient ternary complex with PDGFB and PDGFRB in TGN. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. Note: Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-dependent internalization and recycling at the cell surface. PTM: O-glycosylated By similarity. SEQUENCE SIMILARITIES: Contains 1 Link domain. View All» Product Name: Anti-LYVE1 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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