货号：AB2991

品牌：Merck Millipore

规格：100Ug

目录价：￥4967.00

市场价格：￥4221.95

会员价格：￥3973.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-p32 Antibody | AB2991 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes p32. View All» Molecular Weight: ~ 32 kDa View All» Epitope: Unknown View All» Immunogen: Cocktail of peptides corresponding to the N-terminus of human and mouse p32. View All» Isotype: IgG View All» Background Information: The p32 protein is a doughnut-shaped trimer that is primarily localized in the mitochondria. It has also been reported to be present at the cell surface and in the nucleus. The role of p32 in mammalian cells is unclear. The yeast p32 homologue has been reported to regulate oxidative phosphorylation, and a link to autophagy has been proposed. Elevated expression of p32 in cancer has also been noted. Additionally, p32 is primarily localized in hypoxic/nutrient-deprived regions within tumors and that, in addition to tumor cells, a tumor-associated macrophage/myeloid cell subpopulation closely linked to tumor lymphatics expresses high levels of p32. The expression of p32 at the cell surface, where it can be targeted with p32-binding antibodies and peptides, adds a second level of tumor specificity to p32 expression. The unique expression pattern of p32 in tumor cells, tumor lymphatics, and tumor-associated macrophages/myeloid cells makes p32 a potential target for the diagnosis and therapy of cancer. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with human, mouse, and rat. View All» Application Notes: Immunocytochemistry Analysis: 1:500 dilution from a previous lot detected p32 in HeLa and A431 cells. View All» Control: A431 cell lysate View All» Quality Assurance: Evaluated by Western Blot in A431 cell lysate.Western Blot Analysis: 0.5 µg/ml of this antibody detected p32 on 10 µg of A431 cell lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q07021 View All» Entrez Gene Number: NP_001203 View All» Gene Symbol:
  • C1QBP

  • C1qBP

  • GC1QBP

  • HABP1

  • SF2P32

  • SF2p32

  • gC1Q-R

  • gC1qR

  • p32

  • p33
    View All» Alternate Names:
    • C1q globular domain-binding protein

    • GC1q-R protein

    • Glycoprotein gC1qBP

    • Hyaluronan-binding protein 1

    • Mitochondrial matrix protein p32

    • complement component 1, q subcomponent binding protein

    • splicing factor SF2-associated protein
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry
        View All» Entrez Gene Summary: The human complement subcomponent C1q associates with C1r and C1s in order to yield the first component of the serum complement system. The protein encoded by this gene is known to bind to the globular heads of C1q molecules and inhibit C1 activation. This protein has also been identified as the p32 subunit of pre-mRNA splicing factor SF2, as well as a hyaluronic acid-binding protein. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Not known. Binds to the globular "heads" of C1Q thus inhibiting C1 activation.SUBUNIT STRUCTURE: Interacts with Rubella virus capsid protein. SUBCELLULAR LOCATION: Mitochondrion matrix. SEQUENCE SIMILARITIES: Belongs to the MAM33 family.CAUTION: Was originally thought to be a pre-mRNA splicing factor SF2 p32 subunit and to play a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. View All» Product Name: Anti-p32 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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