货号：AB2994

品牌：Merck Millipore

规格：100Ug

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Phospho-Bid (Ser65) Antibody | AB2994 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: The antibody reacts with the 22 kDa phospho-Bid-S65 protein. View All» Molecular Weight: 22 kDa View All» Epitope: Ser65 View All» Modifications: Phosphorylation View All» Background Information: Bid is a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. Bid induces ICE-like proteases and apoptosis. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the major proteolytic product p15 Bid translocates to mitochondria where it triggers cytochrome c release. View All» Species Reactivity: Human View All» Species Reactivity Note: Reacts with human. Other species have not been tested. View All» Control: Western Blot:: Jurkat cell lysate View All» Quality Assurance: Evaluated by Western Blot on Jurkat cell lysate treated with (+/-) insulin.Western Blot Analysis: A 1:100~500 dilution of this antibody detected phospho-Bid-S65 on jurkat cell lysate treated with (+/-) insulin. View All» Purification Method: Antigen affinity purified View All» Presentation: Purified in PBS with 0.09% NaN3. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P55957-2 View All» Entrez Gene Number: NM_001196.2 View All» Gene Symbol:

• FP497

• MGC15319

• MGC42355

• OTTHUMP00000196197
  View All» Alternate Names:
  • BH3 interacting domain death agonist

  • BH3-interacting domain death agonist

  • BID isoform ES(1b)

  • BID isoform L(2)

  • BID isoform Si6

  • Human BID coding sequence

  • apoptic death agonist

  • desmocollin type 4

  • p22 BID
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq] View All» UniProt Summary: FUNCTION:The major proteolytic product p15 BID allows the release of cytochrome c By similarity. Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2.SUBUNIT STRUCTURE: Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein Bcl-2 By similarity.SUBCELLULAR LOCATION:CytoplasmBy similarity. Mitochondrion membraneBy similarity. Note= When uncleaved, it is predominantly cytoplasmic.BH3-interacting domain death agonist p15: Mitochondrion membraneBy similarity. Note= Translocates to mitochondria as an integral membrane protein By similarity.BH3-interacting domain death agonist p13: Mitochondrion membraneBy similarity. Note= Associated with the mitochondrial membrane By similarity.Isoform 1: Cytoplasm. Ref.3Isoform 3: Cytoplasm. Ref.3Isoform 2: Mitochondrion membrane. Note= A significant proportion of isoform 2 localizes to mitochondria, it may be cleaved constitutively. Ref.3TISSUE SPECIFICITY: Isoforms 2 and 3 are expressed in spleen, bone marrow, cerebral and cerebellar cortex. Isoform 2 is expressed in spleen, pancreas and placenta (at protein level). Isoform 3 is expressed in lung, pancreas and spleen (at protein level). Isoform 4 is expressed in lung and pancreas (at protein level). Ref.3DOMAIN:Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.PTM: TNF-alpha induces a caspase-mediated cleavage of p22 BID into a major p15 and minor p13 and p11 products By similarity.Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.9 Ref.10 View All» Product Name: Anti-Phospho-Bid (Ser65) View All» Concentration: 0.25 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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