货号：AB3077

品牌：Merck Millipore

规格：

目录价：￥4926.00

市场价格：￥4187.10

会员价格：￥3940.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Aquaporin 8 Antibody, colon & pancreas only | AB3077 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Aquaporin 8. The immunogen peptide is unique to Aquaporin-8 without significant homology to other Aquaporins. SPECIES REACTIVITIES: Rat. The peptide has 93% homology with the mouse Aquaporin-8 but species reactivity has not been tested. View All» Epitope: colon & pancreas only View All» Immunogen: A 16 AA synthetic peptide within the C-terminal domain of rat Aquaporin-8 (Koyama et al. 1997; Ishibashi et al. 1997) was selected for antibody production. This domain is predicted to be cytoplasmic. View All» Background Information: Water is a critical component of all living cells. Interestingly, tissue membranes show a great degree of water permeability. Mammalian red cells, renal proximal tubules, and descending thin limb of Henle are extraordinarily permeable to water. Water crosses hydrophobic plasma membranes either by simple diffusion or through a facilitative transport mechanism mediated by special protein "aquaporin". Over the last decade, genes for several members of aquaporin family have been cloned, expressed, and their distribution studied in many tissues. Aquaporin-0 or MIP26 (major intrinsic protein 26 kDa), and Aquaporin-1 (purified from red cells) also called CHIP-28 (channel forming integral protein, 28 kDa; 268 AA; gene locus 7p14) has been the foundation of the growing family of aquaporins. The lens specific Aquaporin-0 represents up to 80% of total lens membrane protein. Defects in MIP26 are a cause of autosomal dominant cataract. The cataract Fraser mutation (CAT-FR or Shriveled) is a transposon-induced splicing error that substitutes a long terminal repeat sequence for the c-terminus of MIP. The lens opacity mutation (LOP) is an AA substitution that inhibits targeting of MIP to the cell membrane. A new water channel, Aquaporin-8, has been identified in rat pancreas and testis by homology cloning (Koyama et al., 1997). Aquaporin-8 (263 aa; 28 kDa) is also found in liver, colon and salivary glands. Aquaporin-8 (APQ8) is expressed in all stages of spermatogenesis. Unlike other AQP, AQP8 has unusually long N-terminus and a short C-terminus. AQP families of proteins are predicted to contain six transmembrane domains. The N and C-terminus are predicted to be cytoplasmic. AQP8 has significant homology to various AQPs: g-TIP (plant water channel, 37%); AQP2 and MIP (37%), AQP1, AQP4, and AQP5 (30-34%); AQP3 (26%). AQP8 does not facilitate glycerol transport. View All» Species Reactivity: Rat View All» Application Notes: Western blot: 1-10 μg/mL using ECL ELISA: 0.5-1.0 μg/mL Immunohistochemistry: We recommend using the affinity purified antibody at 2-10 μg/mL in paraformaldehyde fixed sections of tissues. *Note: It is recommended that 0.5-1% milk is used in all primary/secondary antibody-enzyme conjugate incubations in order to diminish non-specific binding. Optimal working dilutions must be determined by end user. View All» Presentation: Affinity purified immunoglobulin. Liquid in PBS with 0.1% BSA. View All» Storage Conditions: Maintain frozen at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: O94778 View All» Entrez Gene Number: NM_001169.2 View All» Gene Symbol:

• AQP8

• AQP-8

• Aquaporin-8
  View All» Alternate Names: AQP8 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Western Blotting
    View All» Entrez Gene Summary: Aquaporin 8 (AQP8) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 8 mRNA is found in pancreas and colon but not other tissues. View All» UniProt Summary: FUNCTION: SwissProt: O94778 # Forms a water-specific channel; mercury-sensitive. Not permeable to glycerol or urea.SIZE: 261 amino acids; 27381 Da SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Expressed only in pancreas and colon.DOMAIN: SwissProt: O94778 Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family. View All» Brand Family: Chemicon View All» Product Name: Anti-Aquaporin 8 Antibody, colon & pancreas only | AB3077 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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