货号：AB3083

品牌：Merck Millipore

规格：50Ug

目录价：￥5513.00

市场价格：￥4686.05

会员价格：￥4410.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Na+/H+ Exchanger-2 Antibody | AB3083 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: C-terminal domain of the rat NHE2. The antibody is expected to work on human and mouse (20/20) and possibly rabbit (17/20) due to sequence conservation. View All» Immunogen: A 20 AA peptide within the cytoplasmic, C-terminal domain of the rat NHE2 (Collins et al. 1990; Wang et al. 1993; Ghishan et al. 1995; Chris Yun et al. 1995; Josette & Pouyssegur 1995). View All» Background Information: Na+/H+ exchangers (NHE) of mammalian cells are plasma membrane intrinsic proteins mediating exchange of Na+ and H+ ions in various tissues. The NHE catalyzes the electoneuronal transport of extracellular Na+ for intracellular H+. They play a major role in regulation of intracellular pH (pHi) addition to trans-cellular absorption of Na+, cell volume regulation and possibly in cell proliferation. These primary functions of the Na+/H+ exchanger have been related to many pathophysiological states, include hypertension, organ growth and hypertrophy, regression of cancer and renal intestinal disorders. Five isoforms (NHE1-5) have been cloned so far. They are all similar in their primary structure and predicted to have 10-12 transmembrane domains. The COOH-terminals of NHE1, NHE2 and NHE3 are intracellular. NHE2 has been implicated in volume regulation in renal inner medullary collecting duct cells. Its mRNA is found in kidney medulla, cortex, colon, jejunum, ileum, human jejunum, ileum, duodenum, stomach and adrenal glands (Collins et al. 1990; Wang et al. 1993; Ghishan et al. 1995; Chris Yun et al. 1995; Josette & Pouyssegur 1995). View All» Species Reactivity: Rat View All» Application Notes: Western blot: 1-10 μg/mL using Chemiluminescence technique. The molecular weight of NHE2 is approximately 90kDa (Brookstein et al., 1994). ELISA: 1:100,000 using 50-100ng control peptide (AG784)/well. Optimal working dilutions must be determined by end user. View All» Presentation: Liquid in PBS with 0.1% BSA View All» Storage Conditions: Maintain frozen at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 μL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container's cap. View All» UniProt Number: Q9UBY0 View All» Entrez Gene Number: NM_003048.3 View All» Gene Symbol:

• SLC9A2

• Na

• +H

• NHE-2

• NHE2
  View All» Alternate Names: NHE2 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Western Blotting
    View All» UniProt Summary: FUNCTION: SwissProt: Q9UBY0 # Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Seems to play an important role in colonic sodium absorption.SIZE: 812 amino acids; 91520 Da SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Expressed in skeletal muscle, colon and kidney. Lower levels in the testis, prostate, ovary, and small intestine.PTM: Phosphorylated (Possible).SIMILARITY: SwissProt: Q9UBY0 ## Belongs to the Na(+)/H(+) exchanger (TC 2.A.36.5.1) family. View All» Brand Family: Chemicon View All» Product Name: Anti-Na+/H+ Exchanger-2 Antibody | AB3083 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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