货号：AB3092

品牌：Merck Millipore

规格：50Ug

目录价：￥6127.00

市场价格：￥5207.95

会员价格：￥4901.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Orexin-1 Receptor Antibody | AB3092 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes Rat and Human Orexin-1. View All» Molecular Weight: 45-48 kDa View All» Immunogen: A 16 aa peptide near the N-terminus of rat OX1R and a 16 aa peptide near the C-terminus of human OX1R. View All» Background Information: Several peptides associated with feeding behavior have been reported recently. Orexins (Orexin-A and Orexin-B) are a family of hypothalamic neuropeptides selectively expressed in the hypothalamus (Sakurai et al. 1998). Orexin-A and Orexin-B are derived from the same precursor (Prepro-orexin) by proteolytic cleavage. Prepro-orexin is an 130 aa peptide with a putative 33 aa secretory sequence, a hydrophobic core followed by residues with small polar side chains. The expression was detected in brain and to a small extent in testis (Sakurai et al. 1998). These neuropeptides bind and activate two closely related Orexin receptors--G protein coupled receptors (GPCRs) OX1R and OX2R. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Application Notes: Western blot: 1-10 μg/mL using Chemiluminescence technique. Protein runs at 45-48 kDa. ELISA: 1:10,000 -1:100,000 against 50-100 ng/wel immunogen peptide. Optimal working dilutions must be determined by end user. View All» Control: Hypothalamus View All» Purification Method: Immunoaffinity purified View All» Presentation: Affinity Purified immunoglobulin. Liquid in PBS with 0.1% BSA. View All» Storage Conditions: Maintain for 6 months at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. View All» UniProt Number: O43613 View All» Entrez Gene Number: NM_001525.1 View All» Gene Symbol:
  • HCRTR1

  • Ox1r

  • OX1R
    View All» Alternate Names: OX1R; Hypocretin Receptor 1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Western Blotting
      View All» Entrez Gene Summary: HCRTR1, or orexin 1 receptor (OX1R), is a G-protein coupled receptor expressed in the hypothalamus and involved in the regulation of feeding behaviour. HCRTR1 selectively binds the orexin A neuropeptide. It shares 64% identity with HCRTR2. View All» UniProt Summary: FUNCTION: SwissProt: O43613 # Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity).SIZE: 425 amino acids; 47522 Da SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.SIMILARITY: SwissProt: O43613 ## Belongs to the G-protein coupled receptor 1 family. View All» Brand Family: Chemicon View All» Product Name: Anti-Orexin-1 Receptor Antibody | AB3092 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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