货号：AB3120

品牌：Merck Millipore

规格：50Ug

目录价：￥5974.00

市场价格：￥5077.90

会员价格：￥4779.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Angiopoietin-1 Antibody, N-terminus | AB3120 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes mouse Angiopoietin-1 (Ang-1). The immunogenic peptide sequence is 90% (18/20 aa) conserved in human Ang-1, 95% I pig and bovine, and has no significant sequence homology with Ang-2. Antibody crossreactivity in other species is not established. View All» Molecular Weight: 55 kDa View All» Epitope: N-terminus View All» Immunogen: 20 amino acid peptide sequence near the amino-terminus of mouse Ang-1. View All» Background Information: The remodelling of the primitive vasculature in mammals to form the mature cardiovascular system includes a number of factors directing endothelial cell development. Angiopoietin-1 (mouse and human Ang-1; 498aa with 98% identity) is an angiogenic secreted protein that interacts with the endothelial specific Tie-2 receptor. It is primarily expressed in developing endothelial cells. During embryonic dvevelopment, Ang-1 binds and induces tyrosine phosphorylation of Tie-2. Ang-1 appears to play a crucial role in mediating matrix and mesenchyme. It mediates blood vessel maturation and stability. Ang-1 may play a critical role in heart development. Ang-1 deficient mice mimic the phenotype exhibited by animals deficient in Tie-2. A homolog of Ang-1, termed Angiopoietin-2 (mouse and human Ang-2, 496aa with 85% identity) may act as an antagonist for Ang-1 and Tie-2. Ang-1 and Ang-2 have ~60% sequence homology. View All» Species Reactivity: Mouse View All» Application Notes: Western blot: 1-10 ug/mL using ECL. Expected size of Ang-1 is ~55kDa. ELISA: 1:10,000-1:100,000 using 50-100 ng of control peptide per well (Catalog Number AG635). Immunohistochemistry: Not tested. It is recommended that the antibody be used at 2-20 ug/ml in formaldehyde fixed tissue. Optimal working dilutions must be determined by end user. View All» Control: Fetal heart View All» Purification Method: Immunoaffinity purified View All» Presentation: Affinity Purified immunoglobulin. Liquid in PBS with 0.1% BSA. View All» Storage Conditions: Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. View All» UniProt Number: Q15389 View All» Entrez Gene Number: NM_001146.3 View All» Gene Symbol:

• ANGPT1

• ANG1

• ANG-1

• AGP1

• KIAA0003

• Ang1

• AGPT
  View All» Alternate Names: Ang-1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Western Blotting
    View All» Entrez Gene Summary: Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. View All» UniProt Summary: FUNCTION: SwissProt: Q15389 # Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development.SIZE: 498 amino acids; 57513 Da SUBCELLULAR LOCATION: Secreted.PTM: Glycosylated.SIMILARITY: SwissProt: Q15389 ## Contains 1 fibrinogen C-terminal domain.MISCELLANEOUS: It may have a potential therapeutic utility since it can be used for specifically targeting tumor vasculature or for promoting angiogenic processes in certain organs such as an ischemic heart. View All» Brand Family: Chemicon View All» Product Name: Anti-Angiopoietin-1, N-terminus View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 μg View All» Target / Localization: interstitial stem cells destined to become microvascular pericytes. View All» Format: Affinity Purified View All» Host: Rabbit View All»
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