货号：AB3152

品牌：Merck Millipore

规格：100Ug

目录价：￥4967.00

市场价格：￥4221.95

会员价格：￥3973.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Amphiregulin Antibody | AB3152 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes a glycoprotein of 18.5-22.5kDa, identified as amphiregulin (AR). Antibody is directed against the region of AR, which binds to heparin and is highly specific to AR. It shows no cross-reaction with EGF, TGFalpha, or HB-EGF. In vitro, AR functions as an autocrine growth stimulator to derive proliferation of colon carcinoma cells, normal and oncogene-transformed mammary epithelial cells, cervical carcinoma cells, prostate cancer cells, and keratinocytes. AR is important in development of human placenta and murine mammary gland. View All» Immunogen: A synthetic 19-mer peptide, corresponding to aa 26-44 from the secreted amphiregulin of human origin. View All» Species Reactivity:

• Human

• Mouse
  View All» Application Notes: Immunoprecipitation (Use Protein A): Ab 10μg/mg protein lysate. Western Blotting: Ab 5μg/ml for 2hrs at room temperature. Optimal working dilutions must be determined by end user. View All» Presentation: Purified immunoglobulin from rabbit anti-serum by Protein A chromatography. Liquid in 10mM PBS, pH 7.4, with 0.2% BSA and 15mM sodium azide. View All» Storage Conditions: Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months. View All» UniProt Number: P15514 View All» Entrez Gene Number: NM_001657.2 View All» Gene Symbol:
  • AREG

  • MGC13647

  • CRDGF

  • amphiregulin

  • AR

  • SDGF
    View All» Alternate Names: AR; CRDGF; KAF View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Immunoprecipitation

    • Western Blotting
      View All» Entrez Gene Summary: The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. This encoded protein is associated with a psoriasis-like skin phenotype. View All» UniProt Summary: FUNCTION: SwissProt: P15514 # Bifunctional growth-modulating glycoprotein. Inhibits growth of several human carcinoma cells in culture and stimulates proliferation of human fibroblasts and certain other tumor cells.SIZE: 252 amino acids; 27895 Da SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein.SIMILARITY: SwissProt: P15514 ## Belongs to the amphiregulin family. & Contains 1 EGF-like domain. MISCELLANEOUS: AR is a protein containing cysteines in disulfide linkage(s) that are essential for its biological activity. AR may contain oligosaccharides and/or lipid moieties that are not obligatory for the biological activity. View All» Brand Family: Chemicon View All» Product Name: Anti-Amphiregulin Antibody | AB3152 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
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