货号：AB3184

品牌：Merck Millipore

规格：50Ug

目录价：￥4132.00

市场价格：￥3512.20

会员价格：￥3305.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MEK5 Antibody | AB3184 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: MEK 5 is also known as MAP Kinase Kinase 5, or ERK Kinase 5. AB3184 detects a 49 kDa protein, corresponding to the expeted molecular mass of Mek5, in rat brain, rat liver, rat kidney, rat heart, mouse brain, and mouse testis tissue extracts as well as in cell lysates prepared from the rat pheochromacytoma (PC12) and the human HeLa cell lines. No cross-reactivity with MEK 1, 2, 3, 4 or 6 has been observed with this antibody. View All» Immunogen: Human MEK 5 synthetic peptide (aa. 59-74; Genbank Accession # U71088), conjugated to KLH; identical to rat MEK5 sequence over these residues. View All» Species Reactivity:

• Canine

• Human

• Mouse

• Monkey

• Rat

• Rabbit

• Sheep

• Xenopus
  View All» Application Notes: Western Blot: 1 μg/mL Immunohistochemistry: 1:1,000 Immunoprecipitation EIA Optimal working dilutions must be determined by end user. View All» Presentation: Affinity purified immunoglobulin. Affinity purified immunoglobulin Liquid containing PBS, pH 7.2. No preservatives. View All» Storage Conditions: Maintain frozen at -20°C in undiluted aliquots for up to 12 months from date of receipt. Thawed product may be stored at 2-8°C for up to 4 weeks. Avoid repeated freeze/thaw cycles. View All» UniProt Number: Q13163 View All» Entrez Gene Number:
  • NM_002757.2

  • NM_145160.1
    View All» Gene Symbol:
    • MAP2K5

    • MAPKK5

    • HsT17454

    • PRKMK5

    • MEK5

    • MKK5

    • EC 2.7.12.2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • ELISA

      • Immunohistochemistry

      • Immunoprecipitation

      • Western Blotting
        View All» Entrez Gene Summary: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. View All» UniProt Summary: FUNCTION: SwissProt: Q13163 # May participate together with ERK5 in a growth factor stimulated signaling cascade. Specifically activates ERK5, but not other MAP kinases such as ERK2 or p38. Is not phosphorylated by RAFA, RAFB or RAFC. May interact with GTPases such as CDC42.SIZE: 448 amino acids; 50112 Da SUBUNIT: Interacts with PARD6A and MAP3K3. Forms a complex with SQSTM1 and PRKCZ or PRKCI (By similarity). Interacts with Yersinia yopJ.TISSUE SPECIFICITY: Expressed in many adult tissues. Abundant in heart and skeletal muscle.DOMAIN:SwissProt: Q13163 The OPR domain mediates interactions with SQSTM1, PARD6A and MAP3K3 (By similarity).PTM: Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases (By similarity). & Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. & Contains 1 OPR domain. & Contains 1 protein kinase domain. View All» Brand Family: Chemicon View All» Product Name: Anti-MEK5 Antibody | AB3184 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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