货号：AB3201

品牌：Merck Millipore

规格：50Ug

目录价：￥5561.00

市场价格：￥4726.85

会员价格：￥4448.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Tubulin Antibody, Detyrosinated | AB3201 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: The antibody specifically recognizes the detyrosinated form (Glu tubulin) of the tubulin alpha chain (Bianchi, M., 2006; Goulimari, P., 2005). View All» Molecular Weight: 50 kDa View All» Immunogen: Peptide corresponding to the C-terminal of Glu tubulin. View All» Background Information: Microtubules are involved in a wide variety of cellular activities ranging from mitosis and transport events to cell movement and the maintenance of cell shape. Tubulin itself is a globular protein which consists of two polypeptides (alpha and beta tubulin). Alpha and beta tubulin dimers are assembled to 13 protofilaments that form a microtubule of 22 nm diameter. Tyrosine ligase ads a C-terminal tyrosin to monomeric alpha tubulin. Assembled microtubules can again be detyrosinated by a cytoskeleton associated carboxypeptidase. Detyrosinated alpha tubulin is referred to as Glu-tubulin. Another post-translational modification of detyrosinated alpha tubulin is C-terminal polyglutamylation which is characteristic for microtubules in neuronal cells and the mitotic spindle. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Mammals

• Green Plants

• Sea Urchin
  View All» Species Reactivity Note: Human, mouse, and rat. Expected to cross-react with mammals, sea urchin, plants, not yeast (Paturle-Lafanechere, L., 1991). View All» Non-Reactive Species: Yeast (S. cerevisiae) View All» Application Notes: Immunohistochemistry: A previous lot was used on either frozen or paraffin embedded, fixed tissue (Gundersen, G.G., 1984): 1:200-1:500 dilution.Optimal working dilutions must be determined by the end user. View All» Control: Hela Whole Cell Lysate. View All» Quality Assurance: Routinely evaluated by Western Blot on L6 lysate lysates.Western Blot Analysis: 1:500 dilution of this lot detected detyrosinated tubulin on 10 μg of L6 lysate. View All» Purification Method: Affinity purified immunoglobulin View All» Presentation: Purified rabbit polyclonal in buffer containing liquid PBS. View All» Storage Conditions: Stable for 6 months at -20°C in undiluted aliquots from date of receipt.Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: Q13509 View All» Entrez Gene Number: NM_006086.2 View All» Gene Symbol:
  • TUBB3

  • TUBB4

  • MC1R

  • beta-4
    View All» Alternate Names: Glu Tubulin View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunocytochemistry

    • Immunohistochemistry (Paraffin)

    • Western Blotting
      View All» UniProt Summary: FUNCTION: SwissProt: Q13509 # Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.SIZE: 450 amino acids; 50433 Da SUBUNIT: Dimer of alpha and beta chains.DOMAIN: SwissProt: Q13509 The highly acidic C-terminal region may bind cations such as calcium.SIMILARITY: Belongs to the tubulin family. View All» Brand Family: Chemicon View All» Product Name: Anti-Tubulin Antibody, Detyrosinated | AB3201 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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