货号：AB3270

品牌：Merck Millipore

规格：50Ug

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-K+-Cl- Cotransporter 4 Antibody | AB3270 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes K+ Cl- Cotransporter-4 (KCC4). The immunogen shows no significant sequence homology with other KCCs or CCC. SPECIES REACTIVITIES: The immunogen sequence is 81% homologous with human KCC4. Reactivity with other species has not been confirmed. View All» Immunogen: A 16 amino acid peptide within the cytoplasmic, N-terminus of mouse KCC4. View All» Species Reactivity: Human View All» Application Notes: Western blot: 1-10 μg/mL using ECL. Approximate size on reduced westerns is 120-140kDa; membrane preparations and proteinase inhibitors are strongly recommended. See protocol under Technical Service as www.chemicon.com. ELISA: 1:10,000-1:100,000 using 50-100 ng control peptide per well. Optimal working dilutions must be determined by the end user. View All» Presentation: Affinity purified immunoglobulin. Liquid in 100 mM Tris, pH 7.5, containing 0.2% BSA and 0.05% sodium azide. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: Q9Y666 View All» Entrez Gene Number: NM_006598.2 View All» Gene Symbol:

• SLC12A7

• KCC4

• DKFZP434F076
  View All» Alternate Names: KCC4 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Western Blotting
    View All» UniProt Summary: FUNCTION: SwissProt: Q9Y666 # Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity).SIZE: 1083 amino acids; 119106 Da SUBUNIT: Homomultimer and heteromultimer with other K-Cl cotransporters (By similarity).SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Detected in muscle, brain, lung, heart and kidney.SIMILARITY: SwissProt: Q9Y666 ## Belongs to the SLC12A transporter family. MISCELLANEOUS: Activated by N-ethylmaleimide (NEM). Inhibited by furosemide, DIDS and bumetanide. The inhibition is much stronger in the presence of 50 mM K(+) in the uptake medium. Inhibited by DIOA." View All» Brand Family: Chemicon View All» Product Name: Anti-K+-Cl- Cotransporter 4 Antibody | AB3270 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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