货号：AB3296P

品牌：Merck Millipore

规格：

目录价：￥4809.00

市场价格：￥4087.65

会员价格：￥3847.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Na+/HCO3- Cotransporter 3 Antibody, C-terminus | AB3296P View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes human Na+-HCO3- (NBC3). No significant homology with NBC or NBC2. Expected size in reduced western blots human pancreas is 130-135kDa, because NBC is a glycoprotein the band may not be sharp and is higher than the predicted 116kDa size by th cDNA. Membrane preparations and proteinase inhibitors are recommended. SPECIES REACTIVITIES: The immunogen sequence is 83% conserved in rat. Reactivity with other species has not been confirmed. View All» Epitope: C-terminus View All» Immunogen: A 19 amino acid peptide sequence within the cytoplasmic C-terminus of human NBC3 (Pushkin et al. 1999; Choi et al. 1999, gene Accession # AF070475; Amlal et al. 1999; Solemani et al. 2000; Romero et al 1999). View All» Species Reactivity: Human View All» Application Notes: Western blot: 1-10 μg/mL using ECL. ELISA: 1:10,000-1:100,000 using 50-100 ng control peptide per well. Optimal working dilutions must be determined by the end user. View All» Presentation: Affinity purified immunoglobulin. Liquid in phosphate buffered saline, pH 7.4, containing 0.1% BSA and 0.05% sodium azide. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: Q9Y6M7 View All» Entrez Gene Number: NM_003615.3 View All» Gene Symbol:

• SLC4A7

• SLC4A6

• SBC2

• DKFZp686H168

• NBC2

• NBC2B

• NBC3

• BT
  View All» Alternate Names: NBC3 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Western Blotting
    View All» UniProt Summary: FUNCTION: SwissProt: Q9Y6M7 # Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Regulates intracellular pH and may play a role in bicarbonate salvage in secretory epithelia. May also have an associated sodium channel activity.SIZE: 1214 amino acids; 136043 Da SUBUNIT: Interacts with CFTR through SLC9A3R1/EBP50. Interacts with USH1C. Forms a complex with ATP6V1B1 and SLC9A3R1/EBP50. Interacts in a pH dependent-manner with CA2/carbonic anhydrase 2.SUBCELLULAR LOCATION: Basolateral cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein (By similarity). Cell projection, stereocilium (By similarity). Note=Also described at the apical cell membrane. Localizes to the stereocilia of cochlear outer hair cells and to the lateral membrane of cochlear inner hair cells (By similarity).TISSUE SPECIFICITY: Highly expressed in testis and spleen. Also expressed in retina, colon, small intestine, ovary, thymus, prostate, muscle, heart and kidney. Isoform 1 is expressed in skeletal muscle and heart muscle.DOMAIN:"SwissProt: Q9Y6M7 The PDZ-binding motif mediates interaction with the CFTR, SLC9A3R1/EBP50 complex and probably with USH1C.PTM: N-glycosylated (By similarity).SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family. " View All» Brand Family: Chemicon View All» Product Name: Anti-Na+/HCO3- Cotransporter 3 Antibody, C-terminus | AB3296P View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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