货号：AB3349

品牌：Merck Millipore

规格：400UL

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PRMT5 Antibody, C-terminus | AB3349 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Reacts with PRMT5. View All» Epitope: C-terminus View All» Immunogen: Synthetic peptide from C-terminus of human PRMT5. View All» Species Reactivity: Human View All» Application Notes: Western Blot: 1:100-1:500. Reacts with a band of approximately 70 kDa on whole HL60 cell lysate. Additional bands may be present depending on sample used. ELISA (direct): 1:1,000 Optimal working dilutions must be determined by the end user. View All» Control: POSITIVE CONTROL: HL60 cell lysates. View All» Presentation: Purified immunoglobulin in PBS containing 0.09% sodium azide. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: O14744 View All» Entrez Gene Number:

• NM_001039619.1

• NM_006109.3
  View All» Gene Symbol:
  • PRMT5

  • SKB1

  • HRMT1L5

  • IBP72

  • SKB1Hs

  • JBP1

  • EC 2.1.1.125

  • EC 2.1.1.-
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Western Blotting
      View All» UniProt Summary: FUNCTION: SwissProt: O14744 # Methylates specific arginine residues in the small nuclear ribonucleoproteins Sm D1 and Sm D3 to monomethylarginine and to symmetrical dimethylarginines (sDMAs). Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. May regulate the SUPT5H transcriptional elongation properties. May be part of a pathway that is connected to a chloride current, possibly through cytoskeletal rearrangement. Methylates histone H2A/H4 'Arg-3' during germ cell development. Methylates histone H3 'Arg-8', which may repress transcription.SIZE: 637 amino acids; 72684 Da SUBUNIT: Forms, at least, homodimers and homotetramers. Interacts with PRDM1 (By similarity). Component of the methylosome, a 20S complex containing at least pICLn, PRMT1/SKB1 and MEP50. Component of a high molecular weight E2F-pocket protein complex, CERC (cyclin E1 repressor complex). Also interacts with Sm proteins, JAK2, SSTR1 and SUPT5H. Associates with SWI/SNF remodeling complexes containing SMARCA2 and SMARCA4.SUBCELLULAR LOCATION: Cytoplasm.TISSUE SPECIFICITY: Ubiquitous.PTM: Disulfide bonds and non-covalent association mediate homooligomers formation.SIMILARITY: SwissProt: O14744 ## Belongs to the protein arginine N-methyltransferase family. View All» Brand Family: Chemicon View All» Product Name: Anti-PRMT5 Antibody, C-terminus | AB3349 View All» Concentration: 0.25 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
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