货号：AB3430

品牌：Merck Millipore

规格：100UL

目录价：￥5727.00

市场价格：￥4867.95

会员价格：￥4581.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Prosurfactant Protein B Antibody, reacts with both C-terminus and N-terminus View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Reacts strongly with human and mouse proSP-B (detects both the N-terminal and C-terminal propeptides). Does not react with mature SP-B. On human tissue immunostains alveolar Type II cells and non-ciliated bronchiolar cells. On mouse tissue immunostains alveolar Type II cells and non-ciliated bronchiolar (Clara cells) in distal and terminal airways. View All» Epitope: reacts with both C-terminus and N-terminus View All» Immunogen: Full length recombinant peptide (381 a.a.) of the human SP-B (pre)proprotein. View All» Species Reactivity:

• Human

• Mouse
  View All» Application Notes: Immunohistochemistry: 1:4,000-1:8,000 on human tissue with and without antigen retrieval (see protocol on back) and 1:1,000-1:2,000 on adult and fetal mouse lung (see notes on back). Immunoblot: 1:1,000-1:5,000; proprotein 42-46kDa. ELISA: 1:500-1:1,000 Optimal dilutions must be determined by the end user. View All» Presentation: Rabbit serum. Liquid. Contains no preservative. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to twelve months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P07988 View All» Entrez Gene Number:
  • NM_000542.2

  • NM_198843.1
    View All» Gene Symbol:
    • SFTPB

    • SP-B

    • SFTP3

    • Phe

    • PSP-B

    • SFTB3

    • SMDP1
      View All» Alternate Names: proSP-B View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • ELISA

      • Immunohistochemistry

      • Western Blotting
        View All» Entrez Gene Summary: The SFTPB gene encodes the pulmonary-associated surfactant B protein (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a lipid-rich material that prevents lung collapse by lowering surface tension at the air-liquid interface in the alveoli of lung. SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. Surfactant is composed of phospholipids and other surfactant-associated proteins (Clark et al., 1995 [PubMed 7644495]). See also SFTPA1 (MIM 178630), SFTPC (MIM 178620), and SFTPD (MIM 178635).[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: P07988 # Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air- liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.SIZE: 381 amino acids; 42117 Da SUBUNIT: Homodimer; disulfide-linked.SUBCELLULAR LOCATION: Secreted, extracellular space.DISEASE: SwissProt: P07988 # Defects in SFTPB are the cause of pulmonary surfactant metabolism dysfunction type 1 (SMDP1) [MIM:265120]; also called pulmonary alveolar proteinosis due to surfactant protein B deficiency. Inborn errors of pulmonary surfactant metabolism are genetically heterogeneous disorders resulting in severe respiratory insufficiency or failure in full-term neonates or infants. These disorders are associated with various pathologic entities, including pulmonary alveolar proteinosis (PAP), desquamative interstitial pneumonitis (DIP), or cellular non- specific interstitial pneumonitis (NSIP).SIMILARITY: SwissProt: P07988 ## Contains 1 saposin A-type domain. & Contains 3 saposin B-type domains.MISCELLANEOUS: Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C). View All» Brand Family: Chemicon View All» Product Name: Anti-Prosurfactant Protein B Antibody, reacts with both C-terminus and N-terminus View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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