货号：AB3535

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-α-1-Antitrypsin Antibody | AB3535 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Alpha-1 antitrypsin. View All» Immunogen: Synthetic peptides. View All» Species Reactivity: Human View All» Application Notes: Immunoblotting: 1:1,000-1:5,000 ELISA: 1:1,000-1:5,000 Optimal working dilutions must be determined by the end user. View All» Presentation: Affinity purified immunoglobulin. Liquid in PBS containing 0.02% sodium azide. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P01009 View All» Entrez Gene Number:

• NM_000295.3

• NM_001002235.1

• NM_001002236.1
  View All» Gene Symbol:
  • SERPINA1

  • PRO2209

  • PI1

  • MGC23330

  • alpha-1-antitrypsin

  • PRO2275

  • A1AT

  • AAT

  • MGC9222

  • PI

  • A1A
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Western Blotting
      View All» Entrez Gene Summary: Alpha-1-antitrypsin is a protease inhibitor, deficiency of which is associated with emphysema and liver disease. The protein is encoded by a gene (PI) located on the distal long arm of chromosome 14.[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: P01009 # Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity agaisnt insulin and plasmin.SIZE: 418 amino acids; 46737 Da SUBCELLULAR LOCATION: Secreted.TISSUE SPECIFICITY: Plasma.DOMAIN: SwissProt: P01009 The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable.PTM: Several isomers are observed, resulting from the combination of different N-linked glycan structures and mature N-terminus. N- linked glycan at Asn-107 is alternatively di-antennary, tri- antennary or tetra-antennary, whereas glycan at Asn-70 is di- antennary with trace amounts of tri-antennary, and glycan at Asn- 271 is exclusively di-antennary. The structure of the antennas is Neu5Ac(alpha1-6)Gal(beta1-4)GlcNAc attached to the core structure Man(alpha1-6)[Man(alpha1-3)]Man(beta1-4)GlcNAc(beta1-4)GlcNAc. Some antennas are fucosylated, which forms a Lewis-X determinant. & Proteolytic processing may yield the truncated form that ranges from Asp-30 to Lys-418.DISEASE: SwissProt: P01009 # The major physiological function of AAT is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE). A hereditary deficiency of AAT, is associated with a 20-30 fold increased risk of developing chronic obstructive pulmonary disease. & Deficiency of the normal inhibitor in individuals homozygous for allele Z or M-Malton can result in the development of chronic emphysema or infantile liver cirrhosis. & Variant Pittsburgh is the cause of bleeding diathesis.SIMILARITY: Belongs to the serpin family.MISCELLANEOUS: The aberrant form is found in the plasma of chronic smokers, and persists after smoking is ceased. It can still be found ten years after smoking has ceased. View All» Brand Family: Chemicon View All» Product Name: Anti-α-1-Antitrypsin Antibody | AB3535 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Affinity Purified View All» Host: Chicken View All»
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