货号：AB3540P

品牌：Merck Millipore

规格：50Ug

目录价：￥6138.00

市场价格：￥5217.30

会员价格：￥4910.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Monocarboxylate Transporter 1 Antibody | AB3540P View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes rat Monocarboxylate Transporter 1 (MCT1). The immunogen shows no significant sequence homology with MCT2-8. SPECIES REACTIVITIES: The immunogen sequence is 93% conserved in hamster, 80% in mouse and only 40% in human. Reactivity with other species has not been confirmed. View All» Immunogen: A 17 amino acid peptide sequence near the C-terminus of rat MCT1 (Gerhart et al. 1997; Knott et al. 1999; Takanaga et al. 1995; Carpenter et al. 1996; Koehler-Stec et al. 1998; Yoon et al. 1999; Halestrap & Price 1999). View All» Species Reactivity: Rat View All» Application Notes: Western blot: 1-5 μg/mL using ECL. Membrane preps are recommended. ELISA: 1:10,000-1:100,000 using 50-100 ng control peptide per well. Optimal working dilutions must be determined by the end user. View All» Presentation: Liquid in PBS containing 0.1% BSA . View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P53985 View All» Entrez Gene Number: NM_003051.3 View All» Gene Symbol:

• SLC16A1

• MCT

• FLJ36745

• MGC44475

• MCT1
  View All» Alternate Names: MCT1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Western Blotting
    View All» Entrez Gene Summary: The SLC16A1 gene encodes a monocarboxylate transporter (MCT1) that mediates the movement of lactate and pyruvate across cell membranes Import and export of these substrates by tissues such as erythrocytes, muscle, intestine, and kidney are ascribed largely to the action of a proton-coupled MCT (Garcia et al., 1994 [PubMed 8124722]).[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: P53985 # Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate.SIZE: 500 amino acids; 53958 Da SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Widely expressed in normal and in cancer cells.DISEASE: SwissProt: P53985 # Defects in SLC16A1 are the cause of symptomatic deficiency in lactate transport (SDLT) [MIM:245340]; also known as erythrocyte lactate transporter defect. Deficiency of lactate transporter may result in an acidic intracellular environment created by muscle activity with consequent degeneration of muscle and release of myoglobin and creatine kinase. This defect might compromise extreme performance in otherwise healthy individuals.SIMILARITY: SwissProt: P53985 ## Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. View All» Brand Family: Chemicon View All» Product Name: Anti-Monocarboxylate Transporter 1 Antibody | AB3540P View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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