货号：AB3549P

品牌：Merck Millipore

规格：50Ug

目录价：￥5513.00

市场价格：￥4686.05

会员价格：￥4410.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Monocarboxylate Transporter 8 Antibody | AB3549P View All» Replaces: AB3324P View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes mouse Monocarboxylate Transporter 8. View All» Immunogen: A 19 amino acid peptide sequence within the cytoplasmic, C-terminus of mouse MCT8. The immunogen sequence is 94% conserved in rat and 89% in human MCT8 and shows no significant sequence homology with other MCT family members. View All» Background Information: MCT8 is an integral membrane protein that is associated with the plasma membrane. A member of the Major Facilitator Superfamily, MCT8 serves as a proton-linked monocarboxylate transporter that catalyzes the rapid transport of monocarboxylates and ketone bodies across the plasma membrane. Expression of MCT8 is greatest in liver and kidney. View All» Species Reactivity: Mouse View All» Application Notes: Western blot: 1-5 μg/mL using ECL. ELISA: 1:10,000-1:100,000 using 50-100 ng control peptide (Catalog number AG202) per well. Optimal working dilutions must be determined by the end user. View All» Control: POSITIVE CONTROL: Liver or kidney extracts View All» Presentation: Affinitypurified immunoglobulin presented as a liquid in PBS with 0.1% BSA. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 6 months from date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P36021 View All» Entrez Gene Number: NM_006517.2 View All» Gene Symbol:

• SLC16A2

• DXS128E

• DXS128

• MCT8

• AHDS

• XPCT

• MCT7
  View All» Alternate Names: MCT8; X-linked PEST-containing Transporter View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Western Blotting
    View All» UniProt Summary: FUNCTION: SwissProt: P36021 # Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr (By similarity).SIZE: 539 amino acids; 59511 Da SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity).TISSUE SPECIFICITY: Highly expressed in liver and heart.DISEASE: SwissProt: P36021 # Defects in SLC16A2 are the cause of monocarboxylate transporter 8 deficiency (MCT8 deficiency) [MIM:300523]. MCT8 deficiency consists of a severe form of X-linked psychomotor retardation combined with abnormal thyroid hormone (TH) levels. Thyroid hormone deficiency can be caused by defects of hormone synthesis and action, but it has also been linked to a defect in cellular hormone transport. Affected patients are males with abnormal relative concentrations of three circulating iodothyronines, as well as severe neurological abnormalities, including global developmental delay, central hypotonia, spastic quadriplegia, dystonic movements, rotary nystagmus, and impaired gaze and hearing. Heterozygous females had a milder thyroid phenotype and no neurological defects.SIMILARITY: SwissProt: P36021 ## Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. View All» Brand Family: Chemicon View All» Product Name: Anti-Monocarboxylate Transporter 8 Antibody | AB3549P View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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