货号：AB3563

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho mouse HSP25 (pS86) Antibody | AB3563 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Mouse HSP25. Endogenous human HSP27 phosphorylated at serine 82 (HeLa cells treated with TNF-α) was weakly detected by this antibody. View All» Immunogen: The antiserum was produced against a chemically synthesized phosphopeptide derived from a region of mouse HSP25 that contains serine 86. View All» Modifications: Phosphorylation View All» Background Information: Heat Shock Protein 25 (HSP25), is a 25 kDa member of a family of proteins whose expression and function are stimulated by heat shock and other stress stimuli. A major function of these proteins is to serve as chaperones that bind to and stabilize the active conformation of other proteins. HSP25, along with other members of the small HSP group, possesses a C-terminal alpha-crystalline homology domain. HSP25 is localized to the cytoplasm of unstressed cells but can redistribute to the nucleus in response to stress, where it may function to stabilize DNA and/or the nuclear membrane. Cytoplasmic HSP25 exists in multiple complexes. One complex consists of HSP25, Akt (PKB), MAPKAP-kinase 2, and p38 MAPK. The presence of HSP25 in this complex is required for Akt activation by stress stimuli. Another complex consists of HSP25 and the IKK complex. HSP25 is also an actin capping protein that binds to the barbed (growing) ends of actin filaments, thereby inhibiting filament extension. Phosphorylation of HSP25 on serine 86 by MAPKAP-kinase 2 leads to HSP25 dissociation from the Akt/MAPKAP-kinase 2/p38 MAPK complex and from actin filaments, and stimulates HSP25 binding to the IKK complex. View All» Species Reactivity: Mouse View All» Control: NIH3T3 cells treated with anisomycin. View All» Presentation: Dulbecco's phosphate buffered saline (without Mg²⁺ and Ca²⁺), pH 7.3 (+/- 0.1), 50% glycerol with 1.0 mg/mL BSA (IgG, protease free) as a carrier and 0.05% sodium azide View All» Storage Conditions: Store at -20°C. We recommend a brief centrifugation before opening to settle vial contents. Then, apportion into working aliquots and store at -20°C. For shipment or short-term storage (up to one week), 2-8°C is sufficient. View All» UniProt Number: P04792 View All» Entrez Gene Number: NM_001540.2 View All» Gene Symbol:

• HSPB1

• HspB1

• HS.76067

• HMN2B

• Hs.76067

• HSP27

• Hsp25

• HSP28

• CMT2F

• DKFZp586P1322

• SRP27
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: SwissProt: P04792 # Involved in stress resistance and actin organization.SIZE: 205 amino acids; 22783 Da SUBUNIT: Interacts with TGFB1I1 (By similarity). Associates with alpha- and beta-tubulin and microtubules. Interacts with HSPB8 and HSPBAP1.SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock.PTM: Phosphorylated in MCF-7 cells on exposure to protein kinase C activators and heat shock.DISEASE: SwissProt: P04792 # Defects in HSPB1 are the cause of Charcot-Marie-Tooth disease type 2F (CMT2F) [MIM:606595]. CMT2F is a form of Charcot- Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT2 group are characterized by signs of axonal regeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. Nerve conduction velocities are normal or slightly reduced. CMT2F onset is between 15 and 25 years with muscle weakness and atrophy usually beginning in feet and legs (peroneal distribution). Upper limb involvement occurs later. CMT2F inheritance is autosomal dominant. & Defects in HSPB1 are a cause of distal hereditary motor neuropathy (dHMN) [MIM:608634]. Distal HMN is a pure motor peripheral neuropathy without sensory abnormalities.SIMILARITY: SwissProt: P04792 ## Belongs to the small heat shock protein (HSP20) family. View All» Brand Family: Chemicon View All» Product Name: Anti-phospho mouse HSP25 (pS86) Antibody | AB3563 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Rabbit View All»
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